Henrik Enghusen Poulsen took his medical diploma in 1976, and 10 years later he became dr. med. at the University of Copenhagen. From 1996 - 2021 he was professor of the Laboratory of Clinical Pharmacology in Copenhagen. He regularly presents at national and international meetings, and has conducted numerous research studies.
Henrik and co-workers were the first to publish a method that could be used to investigate oxidative stress in humans in vivo, and over the years Henrik has made many epidemiological studies identifying important diseases and factors that relate to oxidation of nucleic acids.
Henrik and co-workers have demonstrated that oxidative stress, measured as formation of the oxidized ribonucleotide of guanine, 8-oxoGuo) is increased in patients with type 2 diabetes, and that high formation is associated with increased mortality and in particular increased mortality from cardiovascular disease. Oxidative stress has long been a major theory for the ageing process, so these data suggest that oxidation of RNA is a quantitative important contribution to the ageing process, and that this ageing process is accelerated in diabetes.
He and co-workers have demonstrated that severe psychiatric diseases such and schizophrenia and bipolar disease are also characterized by increased formation of 8-oxoGuo, and furthermore increased formation of 8-oxoGuo is also seen in thyroid diseases.
Taken together, this suggests that oxidative stress is a quantitative important pathogenic process in several metabolic diseases.
Consultant, senior researcher
Department of Endocrinology I
University Hospital Copenhagen at Bispebjerg Frederiksberg Hospital, Copenhagen NV
Research Unit in Cardiology, Department of Cardiology
University Hospital Copenhagen at Nordsjaellands Hospital, Hillerød
Department of Clinical Medicine, Health Science Faculty
University of Copenhagen
Birkevænget 4, 3050 Humlebæk, Denmark
(45) 4068 3911
Professor Henrik Enghusen Poulsen (HEP) has been awarded the BCPT Nordic Prize 2021 in Basic & Clinical Pharmacology & Toxicology
Increased DNA and RNA damage by oxidation in patients with bipolar I disorder.
Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.