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HENRIK ENGHUSEN POULSEN

INTRODUCTION

ABOUT HENRIK



Henrik Enghusen Poulsen took his medical diploma in 1976, and 10 years later he became dr. med. at the University of Copenhagen. From 1996 - 2021 he was professor of the Laboratory of Clinical Pharmacology  in Copenhagen. He regularly presents at national and international meetings, and has conducted numerous research studies.

OXIDATIVE STRESS IN HUMANS 


Henrik and co-workers were the first to publish a method that could be used to investigate oxidative stress in humans in vivo, and over the years Henrik has made many epidemiological studies identifying important diseases and factors that relate to oxidation of nucleic acids.


Henrik and co-workers have demonstrated that oxidative stress, measured as formation of the oxidized ribonucleotide of guanine, 8-oxoGuo) is increased in patients with type 2 diabetes, and that high formation is associated with increased mortality and in particular increased mortality fromcardiovascular disease.


Oxidative stress has long been a major theory for the ageing process, so these data suggest that oxidation of RNA is a quantitative important contribution to the ageing process, and that this ageing process is accelerated in diabetes. He and co-workers have demonstrated that severe psychiatric diseases such and schizophrenia and bipolar disease are also characterized by increased formation of 8-oxoGuo, and furthermore increased formation of 8-oxoGuo is also seen in thyroid diseases.


Taken together, this suggests that oxidative stress is a quantitative important pathogenic process in several metabolic diseases.

Henrik E. Poulsen is now affiliated with

 

Consultant, senior researcher

Department of Endocrinology I

University Hospital Copenhagen at Bispebjerg Frederiksberg Hospital, Copenhagen NV

Henrik.enghusen.poulsen.01@regionh.dk

 

Consultant

Research Unit in Cardiology, Department of Cardiology

University Hospital Copenhagen at Nordsjaellands Hospital, Hillerød

Henrik.enghusen.poulsen.02@regionh.dk

 

Professor

Department of Clinical Medicine, Health Science Faculty

University of Copenhagen

hepo@sund.ku.dk

 


RECENT WORK



We investigate if a marker in the urine can indicate mortality in type 2 diabetes


The overall aim of my study is to identify an intervention that reduces oxidative stress measured by 8-oxoGuo in patients with for instance type 2 diabetes.

The past decade has provided exciting insights into the role of oxidative stress in the development of for all degenerative deseases.