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(441) Sivalingam, S., Larsen, E. L., van Raalte, D. H., Muskiet, M. H. A., Smits, M. M., Tonneijck, L., Joles, J. A., von Scholten, B. J., Zobel, E. H., Persson, F., Henriksen, T., Diaz, L. J., Hansen, T. W., Poulsen, H. E. & Rossing, P., The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes. 19 maj 2021, I: Scientific Reports. 11, 1, s. 10624 10624.
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(440) Larsen EL, Kjær LK, Lundby-Christensen L, Boesgaard TW, Breum L, Gluud C, Hedetoft C, Krarup T, Lund SS, Mathiesen ER, Perrild H, Sneppen SB, Tarnow L, Thorsteinsson B, Vestergaard H, Poulsen HE, Madsbad S, Almdal TP.
Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial.
Free Radic Biol Med. 2021 Nov 22:S0891-5849(21)00826-1. doi: 10.1016/j.freeradbiomed.2021.11.028. Online ahead of print.
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(439) Anders Jorgensen, Maria Bremholm Thygesen, Uffe Kristiansen and Henrik Enghusen Poulsen. An in silico kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-
dihydroguanosine metabolism from intracellular formation to urinary excretion Scandinavian Journal of Clinical and Laboratory Investigation, DOI:
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(438) Henriksen T, Weimann A, Larsen EL, Poulsen HE. Quantification of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydro-guanosine concentrations in urine and plasma for estimating 24-hour urinary output. Free Radic Biol Med. 2021 Jun 21:S0891-5849(21)00379-8. doi: 10.1016/j.freeradbiomed.2021.06.014.
(437) Treatment of hyperthyroidism reduces systemic oxidative stress, as measured by markers of RNA and DNA damages
Camilla B Larsen, Kamilla Ryom Riis, Kristian Hillert Winther, Emil List Larsen, Christina Ellervik, Laszlo Hegedüs, Thomas Heiberg Brix, Henrik Enghusen Poulsen, Steen Joop Bonnema, 2021, 2021. The Journal of clinical endocrinology and metabolism DOI.
(436) The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the "DOSE-EX" multi-arm parallel-group randomised clinical trial.
Lyngbaek MPP, Legaard GE, Bennetsen SL, Feineis CS, Rasmussen V, Moegelberg N, Brinkløv CF, Nielsen AB, Kofoed KS, Lauridsen CA, Ewertsen C, Poulsen HE, Christensen R, Van Hall G, Karstoft K, Solomon TPJ, Ellingsgaard H, Almdal TP, Pedersen BK, Ried-Larsen M.Trials. 2021 Apr 1;22(1):244. doi: 10.1186/s13063-021-05207-7.PMID: 33794975 Free PMC article.
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Higher systemic oxidatively generated DNA and RNA damage in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives.
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Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals
Ulla Knorr, Rasmus Ahrens Blom, Anja Hviid Simonsen, Henrik Enghusen Poulsen, Morten Akhøj, Julie Forman, Steen Gregers Hasselbalch, Lars Vedel Kessing, 2021, 2021, s. 1-6. Nordic journal of psychiatry DOI.
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Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study
Anders L Sørensen, Hans C Hasselbalch, Mads Emil Bjørn, Claus H Nielsen, Sabrina Cordua, Vibe Skov, Lasse Kjær, Henrik E Poulsen, Christina Ellervik, 2021, bind 41, 2021, s. 101895. Redox biology DOI.
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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
Anders B Klein, Trine S Nicolaisen, Niels Ørtenblad, Kasper D Gejl, Rasmus Jensen, Andreas M Fritzen, Emil L Larsen, Kristian Karstoft, Henrik E Poulsen, Thomas Morville, Ronni E Sahl, Jørn W Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K Pedersen, Wei Lu, Brian Finan, Sebastian B Jørgensen, 2021, bind 12, nummer 1, 2021, s. 1041. Nature communications DOI.
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Quantification of biotin in plasma samples by column switching liquid chromatography - tandem mass spectrometry
Allan Weimann, Peter Plomgaard, Linda M Hilsted, Henrik E Poulsen, Emil L Larsen, 2021, bind 81, nummer 2, 2021, s. 127-136. Scandinavian journal of clinical and laboratory investigation DOI.
(430) The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: A randomized trial
Stine D Søndergård, Ida Cintin, Anja Birk Kuhlman, Thomas Morville, Marie Louise Bergmann, Laura K Kjær, Henrik E Poulsen, Daniela Giustarini, Ranieri Rossi, Flemming Dela, Jørn Wulff Helge, Steen Larsen, 2021, 2021. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme DOI.
2020
(429) Elin Rebecka Carlsson, Mogens Fenger, Trine Henriksen, Laura Kofoed Kjaer, Dorte Worm, Dorte Lindqvist Hansen, Sten Madsbad, Henrik Enghusen Poulsen. Reduction of oxidative stress on DNA and RNA in obese patients after Roux-en-Y gastric bypass surgery-An observational cohort study of changes in urinary markers
2020, bind 15, nummer 12, 2020, s. e0243918. PloS one DOI.
(428) Watt, Sara Kehlet ; Hasselbalch, Hans Carl ; Skov, Vibe ; Kjær, Lasse ; Thomassen, Mads ; Kruse, Torben A ; Burton, Mark ; Poulsen, Henrik Enghusen ; Gögenur, Ismail. Increased oxidative stress with substantial dysregulation of genes related to oxidative stress and DNA repair after laparoscopic colon cancer surgery
Surgical oncology, 2020-12, Vol.35, p.71-78
(427) Kristin Köhler-Forsberg, Anders Jorgensen, Vibeke H. Dam, Dea Siggaard Stenbæk, Patrick M. Fisher, Cheng-Teng Ip, Melanie Ganz, Henrik Enghusen Poulsen, Annamaria Giraldi, Brice Ozenne, Martin Balslev Jørgensen, Gitte Moos Knudsen, and Vibe Gedsoe Frokjaer, Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol Frontiers in psychiatry, 01 July 2020, Vol.11
(426) Nicklas J Johansen, Thomas F Dejgaard, Asger Lund, Camilla Schlüntz, Emil L Larsen, Henrik E Poulsen, Jens P Goetze, Holger J Møller, Tina Vilsbøll, Henrik U Andersen, Filip K Knop. Effect of short-acting exenatide administered three times daily on markers of cardiovascular disease in type 1 diabetes: A randomized double-blind placebo-controlled trial 2020. Diabetes, obesity & metabolism
(425) Emil List Larsen, Henrik Enghusen Poulsen, Cristina Michaelsen, Laura Kofoed Kjær, Mark Lyngbæk, Emilie Skytte Andersen, Christina Petersen-Bønding, Clara Lemoine, Matthew Gillum, Niklas Rye Jørgensen, Thorkil Ploug, Tina Vilsbøll, Filip Krag Knop, Kristian Karstoft, Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study, Journal of sports sciences 2020, s. 1-12
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Anna Jørs, Morten A V Lund, Thomas Jespersen, Torben Hansen, Henrik E Poulsen, Jens-Christian Holm, Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents.Free radical biology & medicine, May 25, 2020 , bind 155, s. 81-86
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Mads Juul Skytte, Amirsalar Samkani, Arne Astrup, Thomas Meinert Larsen, Jan Frystyk, Henrik Enghusen Poulsen, Trine Henriksen, Jens Juul Holst, Ove Andersen, Sten Madsbad, Steen Bendix Haugaard, Thure Krarup, Emil List Larsen
Effects of a Highly Controlled Carbohydrate-Reduced High-Protein Diet on Markers of Oxidatively Generated Nucleic Acid Modifications and Inflammation in Weight Stable Participants With Type 2 Diabetes; A Randomized Controlled Trial. Scand J Clin Lab Invest. 2020 May 6;1-7. doi: 10.1080/00365513.2020.1759137. Online ahead of print.
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Andersson NW, Poulsen HE, Andersen JT. Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study. The Journal of Allergy and Clinical Immunology: In Practice. 2020 Mar;S221321982030177X
(421) Brønden A, Larsen EL, Karstoft K, Henriksen T, Vilsbøll T, Poulsen HE, Knop FK.Changes in oxidative nucleic acid modifications and inflammation following one-week treatment with the bile acid sequestrant sevelamer: Two randomised, placebo-controlled trials. Journal of Diabetes and its Complications. 2020 Feb;34(2):107446.]
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Erik J.M. van Bommel, Marcel H.A. Muskiet1, Michaël J.B. van Baar1, Lennart Tonneijck, Mark M. Smits, Anna L. Emanuel, Andrea Bozovic, A.H. Jan Danser, Frank Geurts, Ewout J. Hoorn, Daan J. Touw, Emil L. Larsen, Henrik E. Poulsen, Mark H.H. Kramer, Max Nieuwdorp, Jaap A. Joles, Daniël H. van Raalte The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial. Kidney International. 2020 Jan;97(1):202.
2019
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Knorr U, Simonsen AH, Roos P, Weimann A, Henriksen T, Christensen EM, Vinberg M, Mikkelsen RL, Kirkegaard T, Jensen RN, Akhøj M, Forman J, Poulsen HE, Hasselbalch SG, Kessing LV. Cerebrospinal fluid oxidative stress metabolites in patients with bipolar disorder and healthy controls: a longitudinal case-control study.
Transl Psychiatry. 2019 Nov 28;9(1):325. doi: 10.1038/s41398-019-0664-6.
PMID: 31780642
(418) Henrik E. Poulsen, Allan Weimann, Trine Henriksen, Laura Kofoed Kjær, Emil List Larsen, Elin Rebecka Carlsson, Cramer K. Christensen, Ivan Brandslund, Mogens Fenger Oxidatively generated modifications to nucleic acids in vivo: Measurement in urine and plasma. Free Radical Biology and Medicine. 2019 Dec;145:336
(417) Emil List Larsen, Allan Weimann, Henrik Enghusen Poulsen Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers. Free Radical Biology and Medicine. 2019 Dec;145:256\
(416) Ottesen NM, Meluken I, Frikke-Schmidt R, Plomgaard P, Scheike T, Fernandes BS, Berk M, Poulsen HE, Kessing LV, Miskowiak K, Vinberg M. Are remitted affective disorders and familial risk of affective disorders associated with metabolic syndrome, inflammation and oxidative stress? - a monozygotic twin study. Psychol Med. 2019 Sep 4:1-10. doi: 10.1017/S003329171900182X. PMID: 3148277
(415) Kofoed Kjær L, Cejvanovic V, Henriksen T, Hansen T,
Pedersen O, Kjeldahl Christensen C, Torp-Pedersen C, Alexander
Gerds T, Brandslund I, Mandrup-Poulsen T, Enghusen Poulsen H.
Urinary nucleic acid oxidation product levels show differential
associations with pharmacological treatment in patients with
type 2 diabetes. Free Radic Res. 2019 Jun 4:1-10. doi:
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(414) D'Souza M, Schou M, Skals R, Weeke PE, Lee C, Smedegaard
L, Madelaire C, Gerds TA, Poulsen HE, Hansen T, Grarup N,
Pedersen O, Stender S, Engstrøm T, Fosbøl E, Nielsen D, Gislason
G, Køber L, Torp-Pedersen C, Andersson C. Polygenic predisposition to breast cancer and the risk of coronary artery disease. International Journal of Cardiology. 2019 Sep;291:145 PMID:
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(413) Falkenberg MK, Teilmann AC, Henriksen T, Hau J, Poulsen HE, Abelson KS. Clinical, Physiologic, and Behavioral Evaluation of Permanently Catheterized NMRI Mice. j am assoc lab anim sci. 2019 May 1;58(3):380 PMID: 30971326
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Weimann A, McLeod G, Henriksen T, Cejvanovic V, Poulsen HE.
Identification and quantification of isoguanosine in humans and
mice. Scand J Clin Lab Invest. 2019 Mar 19:1-8. doi:
10.1080/00365513.2019.1585566. [Epub ahead of print] PMID:
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Jorgensen A, Breitenstein K, Kalliokoski O, Weimann A, Henriksen
T, Poulsen HE, Jorgensen MB, Wörtwein G. Markers of HPA-axis
activity and nucleic acid damage from oxidation after
electroconvulsive stimulations in rats. Acta Neuropsychiatr.
2019 Mar 11:1-29. doi: 10.1017/neu.2019.7. [Epub ahead of print]
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(410) Bjørn
ME, Brimnes MK, Gudbrandsdottir S, Andersen CL, Poulsen HE,
Henriksen T, Hasselbalch HC, Nielsen CH. Ruxolitinib treatment
reduces monocytic superoxide radical formation without affecting
hydrogen peroxide formation or systemic oxidative nucleoside
damage in myelofibrosis. Leuk Lymphoma. 2019 Feb 20:1-9. doi:
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Andersson C, Lukács Krogager M, Kuhr Skals R, Rosenbaum Appel
EV, Theil Have C, Grarup N, Pedersen O, Jeppesen JL, Pedersen
OD, Dominguez H, Dixen U, Engstrøm T, Tønder N, Roden DM,
Stender S, Gislason GH, Enghusen-Poulsen H, Hansen T, Køber L,
Torp-Pedersen C, Weeke PE. Association of genetic variants
previously implicated in coronary artery disease with age at
onset of coronary artery disease requiring revascularizations.
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(408) Ellegaard PK, Licht RW, Nielsen RE, Dean OM, Berk M,
Poulsen HE, Mohebbi M, Nielsen CT.
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randomized placebo-controlled study. J Affect Disord. 2019 Feb
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(407) Kjaer
LK, Grand MK, Siersma V, Broedbaek K, Jorgensen A, de Fine
Olivarius N, Poulsen HE. The effect of structured personal care
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Sørensen AL, Hasselbalch HC, Nielsen CH, Poulsen HE, Ellervik C.
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Thomseth V, Cejvanovic V, Jimenez-Solem E, Poulsen HE, Utheim
TP, Andersen JT. Exposure to antazoline-naphazoline eye drops
during pregnancy and the risk of congenital malformations: a
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(404) Petersen KM, Bøgevig S, Petersen TS, Jensen TB, Dalhoff
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Hemodynamic Effects of Intravenous, High-Dose Lipid Emulsion With and
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Munkholm K, Vinberg M, Pedersen BK, Poulsen HE, Ekstrøm CT,
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oxidation of RNA despite reduced mitochondrial respiration after
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(401) Lukács Krogager M, Skals RK,
Appel EVR, Schnurr TM, Engelbrechtsen L, Have CT, Pedersen O,
Engstrøm T, Roden DM, Gislason G, Poulsen HE, Køber L, Stender
S, Hansen T, Grarup N, Andersson C, Torp-Pedersen C, Weeke PE.
Hypertension genetic risk score is associated with burden of
coronary heart disease among patients referred for coronary
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(400) Cejvanovic V, Kjær LK, Mørup
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(399) Kjaer LK, Oellgaard J, Henriksen
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in urine for the prediction of mortality in patients with type 2
diabetes and microalbuminuria: A post-hoc analysis of the
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(398) Christensen MR, Poulsen HE,
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(397) Franzke B, Schober-Halper B,
Hofmann M, Oesen S, Tosevska A, Henriksen T, Poulsen HE,
Strasser EM, Wessner B, Wagner KH. Age and the effect of
exercise, nutrition and cognitive training on oxidative stress -
The Vienna Active Aging Study (VAAS), a randomized controlled
trial. Free Radic Biol Med. 2018 Jun;121:69-77. doi:
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(396) Larsen EL, Padella L, Bergholdt
HKM, Henriksen T, Santoro L, Gabrielli O, Poulsen HE, Littarru
GP, Orlando P, Tiano L. The effect of long-term treatment with
coenzyme Q10 on nucleic acid modifications by oxidation in
children with Down syndrome. Neurobiol Aging. 2018
Jul;67:159-161. doi: 10.1016/j.neurobiolaging.2018.03.001. Epub
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(395) Ellegaard PK, Licht RW, Poulsen
HE, Nielsen RE, Berk M, Dean OM, Mohebbi M, Nielsen CT. Add-on
treatment with N-acetylcysteine for bipolar depression: a
24-week randomized double-blind parallel group
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Laura K. Kjaer, Henrik Enghusen Poulsen. New method
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(393) Weimann A, Simonsen AH, Poulsen
HE. Measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine and
8-oxo-7,8-dihydro-guanosine in cerebrospinal fluid by ultra
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Sessa M, Mascolo A, Mortensen RN, Andersen MP, Rosano GMC,
Capuano A, Rossi F, Gislason G, Enghusen-Poulsen H,
Torp-Pedersen C. Relationship between heart failure, concurrent
chronic obstructive pulmonary disease and beta-blocker use: a
Danish nationwide cohort study. Eur J Heart Fail. 2018
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(391) Cejvanovic V, Kjaer LK,
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(390) Jorgensen A, Staalsoe JM,
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Progressive DNA and RNA damage from oxidation after aneurysmal
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(387) Naik GS, Ming WK, Magodoro IM,
Akinwunmi B, Dar S, Poulsen HE, Kristensen LE, Ellervik C. Th17
Inhibitors in Active Psoriatic Arthritis: A Systematic Review
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(386) Laura K. Kjær,Vanja Cejvanovic,
Trine Henriksen,Kasper M. Petersen, Torben Hansen, Oluf
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A. Gerds, Ivan Brandslund, Thomas Mandrup-Poulsen, and
Henrik E. Poulsen Cardiovascular and All-Cause Mortality Risk
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(385) Nielsen TK, Højgaard M, Andersen
JT, Jørgensen NR, Zerahn B, Kristensen B, Henriksen T,
Lykkesfeldt J, Mikines KJ, Poulsen HE. Weekly ascorbic acid
infusion in castration-resistant prostate cancer patients: a
single-arm phase II trial. Transl Androl Urol. 2017
Jun;6(3):517-528. doi: 10.21037/tau.2017.04.42. PMID: 28725594
(384) Kessing LV, Munkholm K,
Faurholt-Jepsen M, Miskowiak KW, Nielsen LB, Frikke-Schmidt R,
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GM, Phillips M, Vinberg M.
The Bipolar Illness Onset study: research protocol for the BIO
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8-oxo-7,8-dihydroguanosine as markers of mortality and
cardiovascular disease during 19 years after diagnosis of type 2
diabetes - a comparative study of two markers to identify high
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(382) Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A,
Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G,
Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS,
Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M,
Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D,
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Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG,
Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias
IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P,
Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz
Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J,
Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr
P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M,
Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D,
Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H,
Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J,
Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A,
Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T,
Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM,
Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M,
Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP,
Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F,
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(379) Eck LK, Jensen TB, Mastrogiannis D, Torp-Pedersen A, Askaa
B, Nielsen TK, Poulsen HE, Jimenez-Solem E, Andersen JT. Risk of
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Cejvanovic V, Asferg C, Kjær LK, Andersen UB, Linneberg A,
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(373) Brøsen K, Andersen SE, Borregaard J, Christensen HR, Christensen
PM, Dalhoff KP, Damkier P, Hallas J, Heisterberg J, Jessen N,
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Poulsen BK, Poulsen HE, Andersen LV, Senderovitz T, Sonne J.
Clinical Pharmacology in Denmark in 2016 - 40 Years with the
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(372) Jacoby AS, Vinberg M, Poulsen HE, Kessing LV, Munkholm K.
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(371) Andersen JT, Mastrogiannis D, Andersen NL, Petersen
M, Broedbaek K, Cejvanovic V, Nielsen TK, Poulsen HE,
Jimenez-Solem E. Diclofenac/misoprostol during early
pregnancy and the risk of miscarriage: a Danish nationwide
cohort study. Arch Gynecol Obstet. 2016 Aug;294(2):245-50.
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levels of urinary markers of oxidatively generated DNA and RNA
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May;17(3):257-68. doi: 10.1111/bdi.12245. Epub 2014 Aug 13.
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(369) Sanne Tofte Rasmussen, Jon Trærup Andersen, Torben Kjær
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Henriksen, Allan Weimann, Jens Lykkesfeldt, Henrik Enghusen
Poulsen. Simvastatin and oxidative stress in humans: A
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(368) Torp-Pedersen A, Jimenez-Solem E, Cejvanovic V, Poulsen
HE, Andersen JT. Birth outcomes after exposure to mebendazole
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(367) Nordholm D, Poulsen HE, Hjorthøj C, Randers L, Nielsen MØ,
Wulff S, Krakauer K, Nørbak-Emig H, Henriksen T, Glenthøj B,
Nordentoft M.Systemic oxidative DNA and RNA damage are not
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(366) Ferk F, Mišík M, Nersesyan A, Pichler C, Jäger W, Szekeres
T, Marculescu R, Poulsen HE, Henriksen T, Bono R, Romanazzi V,
Al-Serori H, Biendl M, Wagner KH, Kundi M, Knasmüller S. Impact
of xanthohumol (a prenylated flavonoid from hops) on DNA
stability and other health-related biochemical parameters:
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Apr;60(4):773-86. doi: 10.1002/mnfr.201500355. Epub 2016 Mar 17.
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(365) Julie Tonsgaard Kloppenborg, MD, Cilius Esman
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MD, DMSc, Poul Jannik Bjerrum, DMSc, Henrik Enghusen Poulsen,
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Christian Holm, MD, PhD Urinary markers of nucleic
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Jul;50(7):691-7. doi: 10.3109/10715762.2016.1164310. Epub 2016
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(364) Berendt L, Callréus T, Petersen LG, Bach KF,
Poulsen HE, Dalhoff K. From protocol to published report: a
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Ellegaard PK, Poulsen HE. Tobacco smoking and oxidative stress
to DNA: a meta-analysis of studies using chromatographic and
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Meidahl Petersen K1, Eplov K, Kjær Nielsen T, Jimenez-Solem E,
Petersen M, Broedbaek K, Daugaard Popik S, Kallehave Hansen L,
Enghusen Poulsen H, Trærup Andersen J.
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(361) Frijhoff J, Winyard PG, Zarkovic N, Davies S, Stocker R, Cheng
D, Knight A, Taylor EL, Oettrich J, Ruskovska T, Cipak
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HH, Ghezzi P. Clinical Relevance of Biomarkers of Oxidative
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(360) Bonnema SJ, Stovgaard ES, Fast S, Broedbaek
K, Andersen JT, Weimann A, Grupe P, Hegedüs L, Poulsen HE. Systemic
oxidative stress to nucleic acids is unaltered following
radioiodine therapy of patients with benign nodular goiter. Eur
Thyroid J. 2015 Mar;4(1):20-5. doi: 10.1159/000371883. Epub 2015
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(359) Thomseth V, Cejvanovic V, Jimenez-Solem E,
Petersen KM, Poulsen HE, Andersen JT. Exposure
to topical chloramphenicol during pregnancy and the risk of
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(358) Anders Jorgensen, Ulla Knorr, Mia Greisen
Soendergaard, Jens Lykkesfeldt, Anders Fink-Jensen, Henrik
Enghusen Poulsen, Martin Balslev Jorgensen, Niels Vidiendal
Olsen, Jonatan Myrup Staalsø, Asymmetric dimethylarginine in
somatically healthy schizophrenia patients treated with atypical
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(357) Gidén K, Andersen JT, Torp-Pedersen AL,
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(356) Gjesing A, Gislason GH, Christensen SB,
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(354) Nielsen
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Elimination of Ascorbic Acid following High-Dose Infusion in Prostate
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(353) Skov, M., Pressler, T., Lykkesfeldt, J., Poulsen, H. E.,
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(352) Andersen JT, Andersen NL, Horwitz H,
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miscarriage. Obstet Gynecol 2014 Oct;124(4):655-61.
(351) Bolling R, Scheller NM, Kober L,
Poulsen HE, Gislason GH, Torp-Pedersen C. Comparison of the
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(350) Cejvanovic V, Jimenez-Solem E,
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(349) Rosmarin D1, Palles C, Church D,
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Scudder C, Nicholson G, Gonzalez-Neira A, Martin M, Sargent D,
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Thompson L, Lacas B, Boige V, Ribelles N, Afzal S, Enghusen H,
Jensen SA, Etienne-Grimaldi MC, Milano G, Wadelius M, Glimelius
B, Garmo H, Gusella M, Lecomte T, Laurent-Puig P,
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(347) Munkholm K, Poulsen HE, Kessing LV,
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(346) Poulsen HE, Nadal LL, Broedbaek K,
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(345) Weeke P., Jensen A., Folke F.,
Gislason G. H., Olesen J. B., Fosbol E. L., Wissenberg M.,
Lippert F. K., Christensen E. F., Nielsen S. L., Holm E.,
Kanters J. K., Poulsen H. E., Kober L., Torp-Pedersen C.
Antipsychotics and associated risk of out-of-hospital cardiac
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(344) Bjarke Askaa, Espen Jimenez-Solem,
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2013
(343) Andersen J. T., Petersen M.,
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Broedbaek K., Hjelvang B. R., Kober L., Torp-Pedersen C.,
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(342) Andersen J. T., Petersen M.,
Jimenez-Solem E., Broedbaek K., Andersen N. L., Torp-Pedersen
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(341) Andersen J. T., Petersen M.,
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(340) Barregard L., Moller P., Henriksen
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T., Lam P., Evans M. D., Kasai H., Kawai K., Li Y. S., Sakai K.,
Singh R., Teichert F., Farmer P. B., Rozalski R., Gackowski D.,
Siomek A., Saez G. T., Cerda C., Broberg K., Lindh C., Hossain
M. B., Haghdoost S., Hu C. W., Chao M. R., Wu K. Y., Orhan H.,
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Hansen L. J., Henriksen J. E., Bonnema S. J., de Fine Olivarius
N., Poulsen H. E. Association between urinary markers of nucleic
acid oxidation and mortality in type 2 diabetes: a
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Mar;36(3):669-76.
(338) Broedbaek K, Kasper; Andersen, Jon
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Henriksen, Trine; Weimann, Allan; Parving, Hans-Henrik; Rossing,
Peter; Poulsen, Henrik. RNA oxidation and albuminuria in type 1
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Jimenez-Solem E., Andersen J. T.,
Petersen M., Broedbaek K., Lander A. R., Afzal S., Torp-Pedersen
C., Poulsen H. E. SSRI use during pregnancy and risk of
stillbirth and neonatal mortality. Am J Psychiatry 2013
Mar;170(3):299-304.
(336) Jimenez-Solem E., Andersen J. T.,
Petersen M., Broedbaek K., Andersen N. L., Torp-Pedersen C.,
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(335) Jorgensen A., Broedbaek K.,
Fink-Jensen A., Knorr U., Greisen Soendergaard M., Henriksen T.,
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(334) Jorgensen A., Maigaard K., Wortwein
G., Hageman I., Henriksen T., Weimann A., Moller P., Loft S.,
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in rats causes sustained increase in urinary corticosterone
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(333) Jorgensen A., Krogh J., Miskowiak
K., Bolwig T. G., Kessing L. V., Fink-Jensen A., Nordentoft M.,
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Systemic oxidatively generated DNA/RNA damage in clinical
depression: associations to symptom severity and response to
electroconvulsive therapy. J Affect Disord 2013
Jul;149(1-3):355-62.
(332) Kalliokoski O., Jacobsen K. R.,
Darusman H. S., Henriksen T., Weimann A., Poulsen H. E., Hau J.,
Abelson K. S. Mice do not habituate to metabolism cage
housing--a three week study of male BALB/c mice. PLoS One
2013;8(3):e58460.
(331) Klarskov P., Andersen J. T.,
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2013 Jul;122(1):105-10.
(330) Loft S., Olsen A., Moller P.,
Poulsen H. E., Tjonneland A. Association between
8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of
postmenopausal breast cancer: nested case-control study. Cancer
Epidemiol Biomarkers Prev 2013 Jul;22(7):1289-96.
(329) Mullner E., Brath H., Pleifer S.,
Schiermayr C., Baierl A., Wallner M., Fastian T., Millner Y.,
Paller K., Henriksen T., Poulsen H. E., Forster E., Wagner K. H.
Vegetables and PUFA-rich plant oil reduce DNA strand breaks in
individuals with type 2 diabetes. Mol Nutr Food Res 2013
Feb;57(2):328-38.
(328) Wallner M., Antl N., Rittmannsberger
B., Schreidl S., Najafi K., Mullner E., Molzer C., Ferk F.,
Knasmuller S., Marculescu R., Doberer D., Poulsen H. E., Vitek
L., Bulmer A. C., Wagner K. H. Anti-genotoxic potential of
bilirubin in vivo: damage to DNA in hyperbilirubinemic human and
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2012
(327) Afzal S., Jensen S. A., Sorensen J.
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guanine nucleosides following combination chemotherapy with
5-fluorouracil and oxaliplatin. Cancer Chemother Pharmacol 2012
Feb;69(2):301-7.
(326) Egefjord L., Gejl M., Moller A.,
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neurodegeneration, blood flow and cognition in Alzheimer s
disease - protocol for a controlled, randomized double-blinded
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serotonin reuptake inhibitors and the risk of congenital
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(324) Jorgensen A., Jorgensen M. B.,
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(322) Petersen M., Andersen J. T.,
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H. E. Effect of the Arg389Gly beta(1)-adrenoceptor polymorphism
on plasma renin activity and heart rate, and the
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A. D., Stender S., Torp-Pedersen C., Kober L., Poulsen H. E.
Effect of specific ADRB1/ADRB2/AGT genotype combinations on the
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(319) Sarac S. B., Rasmussen C. H., Afzal
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Exposure to mebendazole and pyrvinium during pregnancy: a Danish
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(317) Tveden-Nyborg P., Hasselholt S.,
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Poulsen H. E., Nielsen S. L., Kober L., Torp-Pedersen C.
Hospital admissions and pharmacotherapy before out-of-hospital
cardiac arrest according to age. Resuscitation 2012
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(315) Weeke P., Jensen A., Folke F.,
Gislason G. H., Olesen J. B., Andersson C., Fosbol E. L., Larsen
J. K., Lippert F. K., Nielsen S. L., Gerds T., Andersen P. K.,
Kanters J. K., Poulsen H. E., Pehrson S., Kober L.,
Torp-Pedersen C. Antidepressant use and risk of out-of-hospital
cardiac arrest: a nationwide case-time-control study. Clin
Pharmacol Ther 2012 Jul;92(1):72-9.
(314) Weimann A., Broedbaek K., Henriksen
T., Stovgaard E. S., Poulsen H. E. Assays for urinary biomarkers
of oxidatively damaged nucleic acids. Free Radic Res 2012
Apr;46(4):531-40.
2011
(313) Afzal S., Gusella M., Vainer B.,
Vogel U. B., Andersen J. T., Broedbaek K., Petersen M.,
Jimenez-Solem E., Bertolaso L., Barile C., Padrini R., Pasini
F., Jensen S. A., Poulsen H. E. Combinations of polymorphisms in
genes involved in the 5-Fluorouracil metabolism pathway are
associated with gastrointestinal toxicity in
chemotherapy-treated colorectal cancer patients. Clin Cancer Res
2011 Jun 1;17(11):3822-9.
(312) Afzal S., Gusella M., Jensen S. A.,
Vainer B., Vogel U., Andersen J. T., Brodbaek K., Petersen M.,
Jimenez-Solem E., Adleff V., Budai B., Hitre E., Lang I., Orosz
E., Bertolaso L., Barile C., Padrini R., Kralovanszky J., Pasini
F., Poulsen H. E. The association of polymorphisms in
5-fluorouracil metabolism genes with outcome in adjuvant
treatment of colorectal cancer. Pharmacogenomics 2011
Sep;12(9):1257-67.
(311) Broedbaek K., Henriksen T., Weimann
A., Petersen M., Andersen J. T., Afzal S., Jimenez-Solem E.,
Persson F., Parving H. H., Rossing P., Poulsen H. E. Long-term
effects of Irbesartan treatment and smoking on nucleic acid
oxidation in patients with type 2 diabetes and microalbuminuria:
an Irbesartan in patients with type 2 diabetes and
Microalbuminuria (IRMA 2) substudy. Diabetes Care 2011
May;34(5):1192-8.
(310) Broedbaek K., Ribel-Madsen R.,
Henriksen T., Weimann A., Petersen M., Andersen J. T., Afzal S.,
Hjelvang B., Roberts L. J., Vaag A., Poulsen P., Poulsen H. E.
Genetic and environmental influences on oxidative damage
assessed in elderly Danish twins. Free Radic Biol Med 2011 Jun
1;50(11):1488-91.
(309) Broedbaek K., Weimann A., Stovgaard
E. S., Poulsen H. E. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
as a biomarker in type 2 diabetes. Free Radic Biol Med 2011 Oct
15;51(8):1473-9.
(308) Broedbaek K., Siersma V., Henriksen
T., Weimann A., Petersen M., Andersen J. T., Jimenez-Solem E.,
Stovgaard E. S., Hansen L. J., Henriksen J. E., Bonnema S. J.,
Olivarius Nde F., Poulsen H. E. Urinary markers of nucleic acid
oxidation and long-term mortality of newly diagnosed type 2
diabetic patients. Diabetes Care 2011 Dec;34(12):2594-6.
(307) Broedbaek K., Siersma V., Andersen
J. T., Petersen M., Afzal S., Hjelvang B., Weimann A., Semba R.
D., Ferrucci L., Poulsen H. E. The association between low-grade
inflammation, iron status and nucleic acid oxidation in the
elderly. Free Radic Res 2011 Apr;45(4):409-16.
(306) Castaner O., Fito M., Lopez-Sabater
M. C., Poulsen H. E., Nyyssonen K., Schroder H., Salonen J. T.,
Torre-Carbot K., Zunft H. F., De la Torre R., Baumler H., Gaddi
A. V., Saez G. T., Tomas M., Covas M. I. The effect of olive oil
polyphenols on antibodies against oxidized LDL. A randomized
clinical trial. Clin Nutr 2011 Aug;30(4):490-3.
(305) Gorovic N., Afzal S., Tjonneland A.,
Overvad K., Vogel U., Albrechtsen C., Poulsen H. E. Genetic
variation in the hTAS2R38 taste receptor and brassica vegetable
intake. Scand J Clin Lab Invest 2011 Jul;71(4):274-9.
(304) Joergensen A., Broedbaek K., Weimann
A., Semba R. D., Ferrucci L., Joergensen M. B., Poulsen H. E.
Association between urinary excretion of cortisol and markers of
oxidatively damaged DNA and RNA in humans. PLoS One
2011;6(6):e20795.
(303) Petersen M., Andersen J. T.,
Hjelvang B. R., Broedbaek K., Afzal S., Nyegaard M., Borglum A.
D., Stender S., Kober L., Torp-Pedersen C., Poulsen H. E.
Association of beta-adrenergic receptor polymorphisms and
mortality in carvedilol-treated chronic heart-failure patients.
Br J Clin Pharmacol 2011 Apr;71(4):556-65.
2010
(302) Nurmi T, Mursu J, Penalvo JL,
Poulsen HE, Voutilainen S. Dietary intake and urinary excretion
of lignans in Finnish men. Br J Nutr 2010 Mar;103(5):677-85.
(301) Lykkesfeldt J, Poulsen HE. Is
vitamin C supplementation beneficial? Lessons learned from
randomised controlled trials. Br J Nutr. 2010 May;103(9):1251-9.
Epub 2009 Dec 15. Review..
(300) Lopez-Miranda J, Perez-Jimenez F,
Ros E, De CR, Badimon L, Covas MI, et al. Olive oil and health:
Summary of the II international conference on olive oil and
health consensus report, Jaen and Cordoba (Spain) 2008. Nutr
Metab Cardiovasc Dis 2010 Mar 19.
(299) Olesen JB, Hansen PR, Erdal J,
Abildstrom SZ, Weeke P, Fosbol EL, et al. Antiepileptic drugs
and risk of suicide: a nationwide study. Pharmacoepidemiol Drug
Saf 2010 Mar 16.
(298) Glintborg B, Andersen SK, Poulsen
HE. Prescription data improve the medication history in primary
care. Qual Saf Health Care 2010 Mar 1.
(297) Sorensen R, Abildstrom SZ, Weeke P,
Fosbol EL, Folke F, Hansen ML, et al. Duration of clopidogrel
treatment and risk of mortality and recurrent myocardial
infarction among 11 680 patients with myocardial infarction
treated with percutaneous coronary intervention: a cohort study.
BMC Cardiovasc Disord 2010;10:6.
(296) de lT-C, Chavez-Servin JL, Jauregui
O, Castellote AI, Lamuela-Raventos RM, Nurmi T, et al. Elevated
circulating LDL phenol levels in men who consumed virgin rather
than refined olive oil are associated with less oxidation of
plasma LDL. J Nutr 2010 Mar;140(3):501-8.
(295) Toward consensus in the analysis of
urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive
biomarker of oxidative stress.
European Standards Committee on Urinary (DNA) Lesion Analysis,
Evans MD, Olinski R, Loft S, Cooke MS. Collaborators
(40) Rossner
P Jr, Sram
R, Henriksen
T, Poulsen
HE, Weimann
A, Barbieri
A, Sabatini
L, Violante
F, Kino
S, Ochi
T, Tairin
K, Takeuchi
M, Kasai
H, Meerman
JH, Gackowski
D, Rozalski
R,Siomek
A, Halliwell
B, Jenner
AM, Wang
H, Cerda
C, Saez
G, Haghdoost
S, Svoboda
P, Hu
CW, Chao
MR, Peng
KY, Shih
WC, Wu
KY, Orhan
H, Istanbullu
NS, Mistry
V, Farmer
PB, Sandhu
J, Singh
R, Cortez
C, Su
Y, Santella
RM, Lambert
P, Smith
R. FASEB
J. 2010 Apr;24(4):1249-60. doi: 10.1096/fj.09-147124. Epub
2009 Dec 4.
(294)
Cadet J, Poulsen
H. Measurement
of oxidatively generated base damage in cellular DNA and urine. Free
Radic Biol Med. 2010
Jun 1;48(11):1457-9. Epub 2010 Mar 12.
(293)
Fosbøl EL, Folke
F, Jacobsen
S, Rasmussen
JN, Sørensen
R, Schramm
TK, Andersen
SS, Rasmussen
S, Poulsen
HE, Køber
L, Torp-Pedersen
C, Gislason
GH. Cause-Specific Cardiovascular Risk Associated With
Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals. Circ
Cardiovasc Qual Outcomes. 2010
Jun 8. [Epub ahead of print]
(292) Weeke P, Folke F, Gislason GH,
Lippert FK, Olesen JB, Andersson C, et al. Pharmacotherapy and
hospital admissions before out-of-hospital cardiac arrest: a
nationwide study. Resuscitation 2010 Dec;81(12):1657-63
(291) Morten L. Hansen, MD, PhD; Rikke
Sørensen, MD; Mette T. Clausen, MSc Pharm; Marie Louise
Fog-Petersen, MSc Pharm; Jakob Raunsø, MD; Niels Gadsbøll, MD,
DMSc; Gunnar H. Gislason, MD, PhD; Fredrik Folke, MD; Søren S.
Andersen, MD; Tina K. Schramm, MD; Steen Z. Abildstrøm, MD, PhD;
Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc; Christian
Torp-Pedersen, MD, DMSc. Risk of Bleeding With Single, Dual, or
Triple Therapy With Warfarin, Aspirin, and Clopidogrel in
Patients With Atrial Fibrillation ARCH INTERN MED/VOL 170 (NO.
16), SEP 13, 2010
(290)
Lykkesfeldt J, Poulsen
HE.Reply to Hemilä by Lykkesfeldt and Poulsen. PMID:
20854702 [PubMed - as supplied by publisher]Br
J Nutr. 2010 Sep
21:1.
(289)
Berendt L, Håkansson
C, Bach
KF, Andreasen
PB, Petersen
LG, Andersen
E, Poulsen
HE, Dalhoff
K. Methodological characteristics of academic clinical drug
trials--a retrospective cohort study of applications to the
Danish Medicines Agency 1993-2005.Br
J Clin Pharmacol. 2010
Nov;70(5):729-35
(288)
Helena Dominguez1*, Tina Kenn Schramm2, Gunnar Hilmar
Gislason3, Mette Lykke Norgaard3, Jakob Raunsø3, Steen Zabell
Abildstrøm4,5, Lars Kober2, Henrik Enghusen Poulsen5,6,7 and
Christian Tobias Torp-Pedersen3,7 National background is
associated with disparities in initiation and persistence to
statin treatment in subjects with diabetes in Denmark. Frontiers
in Pharmacology, Pharmacotherapy of Cardiovascular Disorders
December 2010 | Volume 1 | Article 142 doi:
10.3389/fphar.2010.00142
2009
(287) Poulsen
HE, Andersen
JT, Keiding
N, Schramm
TK, Sørensen
R, Gislasson
G, Fosbøl
EL, Torp-Pedersen
C. Why epidemiological and clinical intervention studies
often give different or diverging results? IUBMB Life, 61(4):
391–393, April 2009
(286) Fosbøl E, Gislason G, Jacobsen S,
Folke F, Hansen M, Schramm T, Sørensen R, Rasmussen J, Andersen
S, Abildstrom S, Trærup J, Poulsen H, Rasmussen S, Køber L,
Torp-Pedersen C. Risk
of Myocardial Infarction and Death Associated With the Use of
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among Healthy
Individuals: A Nationwide Cohort Study. Clin
Pharmacol Ther. (2009); 85, 2, 190–197
(285) Christine Dalgård , Flemming
Nielsen, Jason D. Morrow, Henrik Enghusen-Poulsen, Torbjörn
Jonung, Mogens Hørder and Moniek P. M. de Maat. Supplementation
with orange and blackcurrant juice, but not vitamin E, improves
inflammatory markers in patients with peripheral arterial
disease Br
J Nutr. 2009
Feb;101(2):263-9.
(284) Gunnar H. Gislason, MD, PhD; Jeppe
N. Rasmussen, MD, PhD; Steen Z. Abildstrom, MD, PhD; Tina K.
Schramm, MD;Morten L. Hansen, MD; Emil L. Fosbøl, MB; Rikke
Sørensen, MD; Fredrik Folke, MD; Pernille Buch, MD, PhD; Niels
Gadsbøll, MD, DMSc; Søren Rasmussen, MSc, PhD; Henrik E.
Poulsen, MD, DMSc; Lars Køber, MD, DMSc;
Mette Madsen, MSc; Christian Torp-Pedersen, MD, DMSc. Increased
Mortality and Cardiovascular Morbidity Associated With Use of
Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure.
Arch Intern Med. 2009 Jan 26;169(2):141-9.
(283) Hansen ML, Gadsbøll N, Rasmussen S,
Gislason GH, Folke F, Andersen SS, Schramm TK, Sørensen R,
Fosbøl EL, Abildstrøm SZ, Madsen M, Poulsen HE, Køber L,
Torp-Pedersen C.Clinical
consequences of hospital variation in use of oral anticoagulant
therapy after first-time admission for atrial fibrillation.Journal
of Internal Medicine 265; 335–344
(282) L. F. Mandsberg, O. Ciofu, N.
Kirkby, L. E. Christiansen, H. E. Poulsen and N. Høiby.
Antibiotic Resistance in Pseudomonas aeruginosa Strains with
Increased Mutation Frequency due to Inactivation of the DNA
Oxidative Repair System. Antimicrobial Agents and Chemotherapy,
June 2009, 2483–91
(281) Afzal S, Jensen SA, Vainer B, Vogel
U, Matsen JP, Sorensen JB, et al. MTHFR polymorphisms and
5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol
2009 Oct;20(10):1660-6
(280) Trine Henriksen, Peter R.
Hillestrøm, Henrik E. Poulsen, Allan Weimann. Automated method
for the direct analysis of 8-oxo-guanosine and
8-oxo-2′-deoxyguanosine in human urine using ultraperformance
liquid chromatography and tandem mass spectrometry. Free Radical
Biology & Medicine 47 (2009) 629–635
(279) Broedbaek K, Poulsen HE, Weimann A,
Kom GD, Schwedhelm E, Nielsen P, et al. Urinary excretion of
biomarkers of oxidatively damaged DNA and RNA in hereditary
hemochromatosis. Free Radic Biol Med 2009 Oct 15;47(8):1230-3.
(278) Davanipour Z, Poulsen HE, Weimann A,
Sobel E. Endogenous melatonin and oxidatively damaged guanine in
DNA. BMC Endocr Disord 2009;9:22(
(277)
Poulsen HE. Report from the President of SFRR-Europe. Free
Radical Research, December 2009; 43(12): 1254–1255
(276) Fosbol EL, Gislason GH, Poulsen HE,
Hansen ML, Folke F, Schramm TK, et al. Prognosis in heart
failure and the value of {beta}-blockers are altered by the use
of antidepressants and depend on the type of antidepressants
used. Circ Heart Fail 2009 Nov;2(6):582-90.
(275) Dominguez H, Schramm TK, Norgaard
ML, Abildstrom SZ, Kober L, Jorgensen C, et al. Initiation and
persistence to statin treatment in patients with diabetes
receiving glucose-lowering medications. Open Cardiovasc Med J
2009;3:152-9
2008
(274)
Glintborg B, Poulsen HE, Dalhoff KP.The use of nationwide
on-line prescription records improves the drug history in
hospitalized patients. Br J Clin Pharmacol. 2008
Feb;65(2):265-9;
(273)
Hansen M, Baunsgaard
D, Autrup
H, Vogel
UB, Møller
P, Lindecrona
R, Wallin
H, Poulsen
HE, Loft
S, Dragsted
LO.Sucrose, glucose and fructose have similar genotoxicity
in the rat colon and affect the metabolome.Food
Chem Toxicol.Volume
46, 2008;46:752-60
(272) Berendt L, Håkansson C, Bach KF,
Dalhoff K, Andreasen PB, Petersen LG, Andersen E, Poulsen HE.
Effect of European Clinical Trials Directive on academic drug
trials in Denmark: retrospective study of applications to the
Danish Medicines Agency 1993-2006. BMJ 2008;336;33-35
(271) Morten Lock Hansen, Niels Gadsbøll,
Gunnar H. Gislason, Steen Z. Abildstrom, Tina K. Schramm,
Fredrik Folke, Jens Friberg, Rikke Sørensen, Søren Rasmussen,
Henrik E. Poulsen, Lars Køber, Mette Madsen, and Christian
Torp-Pedersen. Atrial fibrillation pharmacotherapy after
hospital discharge between 1995 and 2004: a shift towards
beta-blockers.Europace. 2008
Apr;10(4):395-402
(270) Serena Guarnieri, Steffen Loft,
Patrizia Riso, Marisa Porrini, Lotte Risom, Henrik E. Poulsen,
Lars O. Dragsted and Peter Møller. DNA repair phenotype and
dietary antioxidant supplementation British Journal of Nutrition
(2008), 99, 1018–1024
(269) Marcus S. Cooke, Ryszard Olinski,
and Steffen Loft members of the European Standards Committee on
Urinary (DNA) Lesion Analysis (ESCULA) ESCULA members include
Mark D. Evans, Rajinder Singh, Vilas Mistry, Peter B. Farmer
(University of Leicester, United Kingdom); Rafal Rozalski,
Daniel Gackowski, Marek Foksinski, Agnieszka Siomek (Nicolaus
Copernicus University, Poland); Peter Møller, Pernille
Danielsen, Elvira Vaklavik, Lykke Forchhammer (University of
Copenhagen, Denmark); Jean Cadet, Jean-luc Ravanat
(CEA/Grenoble, France); Jagadeesan Nair, Urmila Nair (DKFZ,
Germany); Henrik E. Poulsen, Allan Weimann, Peter R. Hillestrom
(Rigshospitalet, Denmark). Measurement and Meaning of
Oxidatively Modified DNA Lesions in Urine. Cancer Epidemiol
Biomarkers Prev 2008;17(1).
(268) Cand.pharm Louise Berendt,
cand.pharm. Cecilia Håkansson, cand.pharm. Karin Friis Bach,
overlæge Kim Dalhoff, overlæge Per Buch Andreasen, cand.pharm.
Lene Grejs Petersen, kontorchef Elin Andersen & professor Henrik
Enghusen Poulsen. Effekten af GCP- direktivet på
forskerinitierede kliniske lægemiddelforsøg –
sekundærpublikation. Ugeskr Laeger. 2008;170:2437-9
(267)
Glintborg B, Olsen
L, Poulsen
H, Linnet
K, Dalhoff
K.Clin
Toxicol (Phila). Reliability
of self-reported use of amphetamine, barbiturates,
benzodiazepines, cannabinoids, cocaine, methadone, and opiates
among acutely hospitalized elderly medical patients. 2008
Mar;46(3):239-42.
(266) Arrigo F.G. Cicero, MD, PhD, Simona
Nascetti, MD, PhD, Maria C. López-Sabater, MD, Roberto Elosua,
MD, Jukka T. Salonen, MD, PhD, Kristiina Nyyssönen, MD, Henrik
E. Poulsen, MD, PhD, Hans-Joachim F. Zunft, MD, PhD, Holger
Kiesewetter, MD, Karina de la Torre, MD, Marıa-Isabel Covas, BD,
PhD, Jari Kaikkonen, Jaakko Mursu, Corina Koenbick, MD, Hans
Bäumler, MD, PhD, and Antonio V. Gaddi, MD, PhD, for the
EUROLIVE Study Group. Changes in LDL fatty acid composition as a
response to olive oil treatment are inversely related to lipid
oxidative damage: The EUROLIVE Study. Journal of the American
College of Nutrition, 2008;27:314–20
(265)
Gottipati KR, Poulsen
H, Starcher
B. Passive cigarette smoke exposure inhibits ultraviolet
light B-induced skin tumors in SKH-1 hairless mice by blocking
the nuclear factor kappa B signalling pathway.Exp
Dermatol. 2008
Sep;17(9):780-7.
2007
(264) Machowetz A, Poulsen HE, Gruendel S,
Weimann A, Fito M, Marrugat J, de la Torre R, Salonen JT,
Nyyssonen K, Mursu J, Nascetti S, Gaddi A, Kiesewetter H,
Baumler H, Selmi H, Kaikkonen J, Zunft HJ, Covas MI, Koebnick C.
Effect of olive oils on biomarkers of oxidative DNA stress in
Northern and Southern Europeans The FASEB Journal • Research
Communication. The FASEB Journal. 2007;21:45-52.
(263) Bondia-Pons I, Schroder H, Covas MI,
Castellote AI, Kaikkonen J, Poulsen HE, Gaddi AV, Machowetz A,
Kiesewetter H, Lopez-Sabater MC.Moderate Consumption of Olive
Oil by Healthy European Men Reduces Systolic Blood Pressure in
Non-Mediterranean Participants.
J Nutr. 2007 Jan;137(1):84-87.
(262) Tuomainen TP, Loft S, Nyyssonen K,
Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor
to oxidative damage of DNA. Free Radic. Res. 2007
Mar;41(3):324-8.
(261)
Bader N, Bosy-Westphal A, Koch A, Rimbach G, Weimann A, Poulsen
HE, Muller MJ Effect
of hyperbaric oxygen and vitamin C and E supplementation on
biomarkers of oxidative stress in healthy men. Br J Nutr.
2007 Oct;98(4):826-33 261) Gravholt
CH, Poulsen
HE, Ott
P, Christiansen
JS,Vilstrup
H. Quantitative liver functions in Turner syndrome with and
without hormone replacement therapy. Eur J Endocrinol. 2007
Jun;156(6):679-86.
(260)
Glintborg B, Hillestrom PR, Olsen LH, Dalhoff KP, Poulsen HE. Are
patients reliable when self-reporting medication use? Validation
of structured drug interviews and home visits by drug analysis
and prescription data in acutely hospitalized patients. J Clin
Pharmacol. 2007 Nov;47(11):1440-9.
(259)
Vitamin C deficiency in weanling guinea pigs: differential
expression of oxidative stress and DNA repair in liver and
brain. Lykkesfeldt
J, Trueba GP, Poulsen HE, Christen S. Br J Nutr. 2007
Dec;98(6):1116-9.
2006
(258) Hillestrom PR, Weimann A, Poulsen
HE.Quantification of Urinary Etheno-DNA Adducts by
Column-Switching LC/APCI-MS/MS. J Am Soc Mass
(257) Hillestrom PR, Weimann A, Jensen,
CB, Storgaard H, Vaag AA, Poulsen HE. Consequences of low
birthweight on urinary excretion of DNA markers of oxidative
stress in young men. Scand J Clin Lab Invest 2006; 66: 363–70.
(256) Hillestrom PR, Covas MI, Poulsen HE.
Effect of dietary virgin olive oil on urinary excretion of
etheno-DNA adducts. Free Radic Biol Med. 2006 Oct
1;41(7):1133-8. Epub 2006 Jul 4.
(255) Covas MI, Nyyssonen K, Poulsen HE,
Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi A, de la Torre R,
Mursu J, Baumler H, Nascetti S, Salonen JT, Fito M, Virtanen J,
Marrugat J, EUROLIVE Study Group. The effect of polyphenols in
olive oil on heart disease risk factors: a randomized trial. Ann
Intern Med. 2006 Sep 5;145(5):333-41.
(254) Glintborg B, Weimann A, Kensler TW,
Poulsen HE. Oltipraz chemoprevention trial in Qidong, People's
Republic of China: Unaltered oxidative biomarkers. Free Radic
Biol Med. 2006 Sep 15;41(6):1010-4.
2005
(253) Riis B, Poulsen HE, Repair and
Removal Systems DNA Repair: Mechanisms and Measurements In:The
Handbook of Environmental Chemistry Vol. 2, Part O. eds.
Springer-Verlag Berlin Heidelberg 2005: 151–75
(252) Weimann A, Sabroe M, Poulsen HE
Measurement of caffeine and five of the major metabolites in
urine by high-performance liquid chromatography/tandem mass
Spectrom. 2005;40:307-16
(251) Hillestrøm PR, Nyssönen K, Tuomainen
T-P, Pukkala E, Salonen JT, Poulsen HE Urinary excretion of of
edA is not predictive of cancer development: A prospective
nested case control study. Free Rad Research, 2005;39:51-3
(250) Ciofu O, Riis B, Pressler T, Poulsen
HE, Hoiby N Occurrence of Hypermutable Pseudomonas aeruginosa in
Cystic Fibrosis Patients Is Associated with the Oxidative Stress
Caused by Chronic Lung Inflammation. Antimicrob. Agents
Chemother. 2005;49:2276-2282
(249) Laska MJ, Nexo BA, Vistisen K,
Poulsen HE, Loft S, Vogel U Polymorphisms in RAI and in genes of
nucleotide and base excision repair are not associated with risk
of testicular cancer. Cancer Lett. 2005;225:245-51
(248) Dalhoff KP, Poulsen HE.[Toxicology
and pharmacogenetics] Ugeskr Laeger. 2005;167:2170-2. Danish.
(247) Poulsen HE. Oxidative DNA
modifications. Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:161-9.
Review.
(246) Gronbaek K, Sonne J, Ring-Larsen H,
Poulsen HE, Friis H, Bygum Krarup H. Viral load is a negative
predictor of antioxidant levels in hepatitis C patients .Scand J
Infect Dis. 2005;37:686-9
(245) Dalhoff K, Jensen KB, Poulsen HE.
Cancer and molecular biomarkers of phase 2. In: John Abelson,
USA, ed. Methods Enzymol. 400 ed. New York: Elsevier;
2005:618-27
2004
(244) Hoberg AM, Otteneder M, Marnett LJ,
Poulsen HE. Measurement of the malondialdehyde-2'-deoxyguanosine
adduct in human urine by immuno-extraction and liquid
chromatography/atmospheric pressure chemical ionization tandem
mass spectrometry.J Mass Spectrom. (2004); 39(1):38-42.
(243) Collins AR, Cadet J, Möller L,
Poulsen HE, Vina J. Are we sure we know how to measure
8-oxo-7,8-dihydroguanine in DNA from human cells? Archives of
Biochemistry and Biophysics 423 (2004) 57-65
(242) Poulsen HE, Moller P, Lykkesfeldt J,
Weimann A, Loft S. Vitamin C and oxidative damage to DNA. In:
Vitamin C, edited by Han Asard, James M. May and Nicholas
Smirnoff, BIOS Scientific Publishers Ltd, Oxford 2004:189-202
(241) Vistisen K, Loft S, Olsen JH,
Vallentin S, Ottesen S, Hirsch FR, Poulsen HE. Low CYP1A2
activity associated with testicular cancer. Carcinogenesis. 2004
Jun;25(6):923-929
(240) Hillestrom PR, Hoberg AM, Weimann A,
Poulsen HE. Quantification of 1,N6-etheno-2'-deoxyadenosine in
human urine by column-switching LC/APCI-MS/MS. Free Radic Biol
Med. 2004 Jun 1;36(11):1383-92
(239) Weimann A, Riis B, Poulsen HE.
Oligonucleotides in human urine do not contain
8-oxo-7,8-dihydrodeoxyguanosine. Free Radic Biol Med. 2004
1;36(11):1378-82
(238) de Waard H de Wit J, Andresson J-O,
van Oostrom CTM, Riis B, Weimann A, Poulsen HE, van Steeg H,
Hoeijmakers JHJ, van der Horst GTJ. Different Effects of CSA and
CSB Deficiency on Sensitivity to Oxidative DNA Damage Molecular
and Cellular Biology, (2004);24:7941-8
(237) Møller, P,Viscovich M, Lykkesfeldt
J, Loft S, Jensen A, Poulsen HE. Vitamin C supplementation
decreases oxidative DNA damage in mononuclear blood cells of
smokers. European Journal of Nutrition 2004 Jan;1-8
(236) Lykkesfeldt J, Viscovich M, Poulsen
HE. Plasma malondialdehyde is induced by smoking: a study with
balanced antioxidant profiles. Br J Nutr. 2004;92(2):203-6.
(235) Viscovich M, Lykkesfeldt L, Poulsen
HE. Vitamin C pharmacokinetics of plain and slow release
formulations in smokers Clinical Nutrition (2004) 23,1043-50
(234) Hansen M, Hald MT, Autrup H, Vogel
U, Bornholdt J, Moller P, Molck AM, Lindecrona R, Poulsen HE,
Wallin H, Loft S, Dragsted LO. Sucrose and IQ induced mutations
in rat colon by independent mechanism.Mutat Res. 2004 Oct
4;554(1-2):279-86
(233) ESCODD (European Standards Committee
on Oxidative DNA Damage). Establishing the background level of
base oxidation in human lymphocyte DNA: results of an
interlaboratory validation study. The FASEB Journal express
article10.1096/fj.04-1767fje. Published online November 8
(232)
Poulsen HE. Alkoholelimination i alkopops. Ugeskr
Laeger. 2004;166:4449.
(231) Poulsen HE, Dalhoff KP. Mangelfuld
registrering af lægemiddelforgiftninger og – bivirkninger i
Danmark. Ugeskr Laeger. 2004;166:4451
2003
(230) Salonen RM, Nyyssonen K, Kaikkonen
J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH et al.
Six-year effect of combined vitamin C and E supplementation on
atherosclerotic progression - The Antioxidant Supplementation in
Atherosclerosis Prevention (ASAP) study. Circulation 2003;
107(7):947-953.
(229) Collins A, Gedik C, Vaughan N, Wood
S, White A, Dubois J et al. Measurement of DNA oxidation in
human cells by chromatographic and enzymic methods. Free Radical
Biology and Medicine 2003; 34(8):1089-1099.
(228) Bruunsgaard H, Poulsen HE, Pedersen
BK, Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combined
supplementations with alpha-tocopherol and vitamin C have no
detectable anti-inflammatory effects in healthy men.Journal of
Nutrition 2003;133:1170-1173
(227) Lykkesfeldt J, Bolbjerg ML, Poulsen
HE. Effect of smoking on erythorbic acid pharmacokinetics.
British Journal of Nutrition 2003; 89:667-671
(226) Osterberg O, Kiehr B, Erichsen L,
Poulsen HE, Ingwersen SH. Pharmocokinetics and allometric
scaling of levormeloxifene, a selective oestrogen receptor
modulator. Biopharm Drug Dispos. 2003;24:121-129.
(225) Verhagen H, Aruoma OI, van Delft JH,
Dragsted LO, Ferguson LR, Knasmuller S, Pool-Zobel BL, Poulsen
HE, Williamson G, Yannai S. The 10 basic requirements for a
scientific paper reporting antioxidant, antimutagenic or
anticarcinogenic potential of test substances in in vitro
experiments and animal studies in vivo. Food Chem Toxicol
2003;41(5):603-10
(224) Vogel U, Danesvar B, Autrup H, Risom
L, Weimann A, Poulsen HE, Moller P, Loft S, Wallin H, Dragsted
LO. Effect of increased intake of dietary animal fat and fat
energy on oxidative damage, mutation frequency, DNA adduct level
and DNA repair in rat colon and liver. Free Radic Res.
2003;37(9):947-56.
(223) Møller P, Daneshvar B, Loft S,
Wallin H, Poulsen HE, Autrup H, Ravn-Haren G, Dragsted LO.
Oxidative DNA damage in vitamin C-supplemented guinea pigs after
intrtracheal instillation of diesel exhaust particles.
Toxicology and Applied Pharmacology 2003;189:39-44.
(222) Møller P, Hansen M, Autrup H,
Bornholt J, Vogel U, Mølck A-M, Wallin H , Dragsted LO,
Risom L, Poulsen HE, Loft S. Dietary low-dose sucrose
modulation of IQ-induced genotoxicity in the colon and liver of
Big Blue™ rats Mutation Research/Fundamental and Molecular
Mechanisms of Mutagenesis 2003; 527:91-97
(221) Dybdahl M, Risom L, Moller P, Autrup
H, Wallin H, Vogel U, Bornholdt J, Daneshvar B, Dragsted L,
Weimann A, Poulsen HE, Loft S. DNA adduct formation and
oxidative stress in colon and liver of Big Blue(R) rats after
dietary exposure to diesel particles.Carcinogenesis. 2003
Nov;24(11):1759-66
(220) Loft S, Kold-Jensen T, Hjollund NH,
Giwercman A, Gyllemborg J, Ernst E, Olsen J, Scheike T, Poulsen
HE, Bonde JP. Oxidative DNA damage in human sperm influences
time to pregnancy.Hum Reprod. 2003;18(6):1265-72.
(219) Poulsen HE, Gronlykke TB [Does the
public sector have an independent research role in the
development of drugs?]
Ugeskr Laeger. 2003 Apr 14;165(16):1674-6. Danish.
(218) Risom L, Moller P, Hansen M, Autrup
H, Bornholdt J, Vogel U, Wallin H, Poulsen HE, Dragsted LO, Loft
S. Dietary elevated sucrose modulation of diesel-induced
genotoxicity in the colon and liver of Big Blue rats. Arch
Toxicol 2003;77:651-6
(217) Lykkesfeldt J, Viscovich M, Poulsen
H. Ascorbic acid recycling in human erythrocytes is induced by
smoking in vivo. FRBM 2003;35:1439-47.
(216) Kramer I, Dalhoff K, Clemmensen JO,
Loft S, Poulsen HE, Comparison of chlorzoxazone one-sample
methods to estimate CYP2E1 activity in humans. Eur J Clin Pharm
2003; 59:775-8
(215) Osterberg O, Erichsen L, Ingwersen
SH, Plum A, Poulsen HE, Vicini P.Pharmacokinetic and
pharmacodynamic properties of insulin aspart and human insulin.
J Pharmacokinet Pharmacodyn. 2003 Jun;30(3):221-35.
(214) Loft, S., Møller, P., Vogel, U.,
Risom. L., Sørensen, M., Riis, B., Poulsen, H.E., Dybdahl, M.,
and Wallin, H. (2003) Oxidative Stress by Environmental Agents,
Journal of University of Occupational and Environmental Health
2003;25(suppl.1):47-59
2002
(213) Weimann, A, Belling D, Poulsen HE.
Quantification of 8-oxoGuanine and Guanine as the Nucleobase,
Nucleoside and Deoxynucleoside forms in Human Urine by High
Preformance Liquid Chromatography - Electrospray Tandem Mass
Spectrometry. Nucleic Acids Research 2002; 30 no.2 e 7
(212) Kaikkonen, J, Porkkala-Sarataho, E,
Morrow JD, Jackson Roberts II, L, Nyyssönen, K, Salonen, R,
Tuomainen, TP, Ristonmaa, U, Poulsen, HE, Salonen JT.
Supplementation with Vitamin E but not with Vitamin C Lowers
Lipid Peroxidation In Vivo in Mildly Hypercholesterolemic Men.
Free Radical Researchs, 2002; 35:967-978
(211) Schmidt,L.E., Dalhoff,K.
Poulsen,H.E. Acute versus chronic alcohol consumption in
acetaminophen-induced hepatotoxicity, Hepatology, 2002,
35:876-882
(210) ESCODD. Inter-laboratory Validation
of Procedures for Measuring
8-oxo7,8-dihydrogunanine/8-oxo-7,8-dihydro-2´-deoxyguanosine in
DNA. Free Radical Research, 2002; 36 (3):239-245
(209) Riis, Bente and ESCODD. Comparison
of Results from Different Laboratories in Measuring
8-oxo-2´-deoxyguanosine in Synthetic Oligonucleotides. Free
Radical Research, 2002; 36 (3): 649-659.
(208) B, Risom L, Loft S, Poulsen H.E.
Increased rOGG1 expression in regenerating rat liver tissue
without a corresponding increase in incision activity. DNA
Repair, 2002; (1): 419-424
(207) Møller P, Wallin H, Vogel U, Autrup
H,Risom l, Hald M.T., Daneshvar B, Dragsted L.O., Poulsen H.E.,
Loft S. Mutagenicity of 2-amino-3methylimidazo [4,5f] quinoline
in colon and liver of Big Blue rats: role of DNA adducts, strand
breaks, DNA repair and oxidative stress. Carcinogenesis, 2002;
23(8): 1379-1385.
(206) Dragsted L.O., Daneshvar B, Vogel U,
Autrup H.N., Wallin H, Risom L, Møller P, Mølck A.M., Hansen M,
Poulsen H.E., Loft s. A sucrose-rich Diet Induces Mutation in
the Rat Colon. Cancer Research, 2002; 62: 4339-4345.
(205) Escodd (European Standards Comittee
on Oxidative DNA Damage). Comparative analysis of baseline
8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different
methods in different laboratories: an approach to consensus.
Carcinogenesis, 2002;23(12): 2129-2133.
(204) Riis B, Risom L, Loft S, Poulsen HE.
OGG1 m RNA expression and incision activity in rats are higher
in foetal tissue than in adult liver tissue while
8-oxo-2'-deoxyguanosine levels are unchanged. DNA Repair
2002;1:709-17.
(203) Clinical pharmacology
2001--important events. The Danish Society of Clinical
Pharmacology]
Ugeskr Laeger. 2002 Mar 18;164(12):1652.
2001
(202) Dalhoff K, Laursen H, Bangert K,
Poulsen HE, Anderson ME, Grunnet N et al. Autoprotection in
acetaminophen intoxication in rats: the role of liver
regeneration. Pharmacol Toxicol 2001; 88(3):135-141.
(201) Weimann A, Belling D, Poulsen HE.
Measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine
in DNA and Human Urine by High Performance Liquid
Chromatography-Electrospray Tandem Mass Spectrometry. Free Rad
Biol Med 2001; 30:757-764.
(200) Schmidt LE, Rasmussen A, Norrelykke
MR, Poulsen HE, Hansen BA. The effect of selective bowel
decontamination on the pharmacokinetics of mycophenolate mofetil
in liver transplant recipients. Liver Transpl 2001;
7(8):739-742.
(199) Sorensen M, Jensen BR, Poulsen HE,
Deng X, Tygstrup N, Dalhoff K et al. Effects of a Brussels
sprouts extract on oxidative DNA damage and metabolising enzymes
in rat liver. Food Chem Toxicol 2001; 39(6):533-540.
(198) Nielsen HB, Kharazmi A, Bolbjerg ML,
Poulsen HE, Pedersen BK, Secher NH. N-acetylcysteine attenuates
oxidative burst by neutrophils in response to ergometer rowing
with no effect on pulmonary gas exchange. Int J Sports Med 2001;
22 (4):256-260.
(197) Laursen JB, Boesgaard S, Trautner S,
Rubin I, Poulsen HE, Aldershvile J. Endothelium-dependent
vasorelaxation is inhibited by in vivo depletion of vascular
thiol levels:role of endothelial nitric oxide synthase. Free Rad
Res 2001; 35:387-394.
(196) Gaede P, Poulsen HE, Parving HH, Pedersen
O. Double-blind, randomised study of the effect of combined
treatment with vitamin C and E on albuminuria in Type 2 diabetic
patients. Diabetic Medicine 2001; 18 :756-760.
(195) Hoberg, AM, Poulsen HE. Analysis of
a promutagenic exocyclic DNA adduct in human urine by HPLC APCI
tandem mass spectrometry. Advances in Mass Spectrometry, 2001;
15:597-598.
2000
(194) ESCODD (European Standards Committee
on Oxidative DNA Damage) Comparison of different Methods of
Measuring 8-oxoguanine as a Marker of Oxidative DNA Damage.Free
Rad. Res 2000; 32:333-341
(193) Loft S, Poulsen HE. Antioxidant
Intervention Studies Related to DNA Damage, DNA Repair and Gene
Expression. Free Rad Res 2000; 33:S67-83
(192) Dalhoff KP, Poulsen HE. Talidomid
fiasko eller succes. Ugeskr Laeger 2000; 162(1):52-53.
(191) Porkkala-Sarataho E, Salonen JT,
Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U et al.
Long-term effects of vitamin E, vitamin C, and combined
supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine,
serum cholesterol oxidation products, and oxidation resistance
of lipids in nondepleted men. Arterioscler Thromb Vasc Biol
2000; 20(9):2087-2093.
(190) Poulsen HE,
Jensen BR, Weimann A, Jensen SA, Sørensen M, Loft S.
Antioxidants, DNA damage and gene expression. Free Rad Res 2000;
33:S33-39
(189) Salonen JT, Nyyssonen K, Salonen R,
Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. Antioxidant
Supplementation in Atherosclerosis Prevention (ASAP) study: a
randomized trial of the effect of vitamins E and C on 3-year
progression of carotid atherosclerosis. J Intern Med 2000;
248(5):377-386.
(188) Jingsheng Tuo, Li Liu, Henrik E.
Poulsen, Allan Weimann, Ove Svendsen and Steffen Loft.
Importance of guanine nitration and hydroxylation in DNA in
vitro and in vivo. Free Radical Biology & Medicine
2000;29:147-155
(187) Voutilainen S, Lakka TA, Hamelahti
P, Lehtimaki T, Poulsen HE, Salonen JT. Plasma total
homocysteine concentration and the risk of acute coronary
events: the Kuopio Ischaemic Heart Disease Risk Factor
Studytpdel. J Intern Med 2000; 248(3):217-222.
(186) Wellejus A, Poulsen HE, Loft S.
Iron-induced oxidative DNA damage in rat sperm cells in vivo and
in vitro. Free Radic Res 2000; 32(1):75-83.
(185) Wellejus A, Poulsen HE, Loft S.
Iron-induced oxidative DNA damage in rat sperm cells in vivo and
in vitro. Free Radic Res 2000; 32(1):75-83.
(184) Zhu C, Poulsen HE, Loft S.
Inhibition of oxidative DNA damage in vitro by extracts of
brussels sprouts [In Process Citation]. Free Radic Res 2000;
33(2):187-196.
1999
(183) Jensen SA, Jensen BR, Weiman
A, Li L, Poulsen HE. [Oxidative stress and aging]. Ugeskr Laeger
1999; 162(17):2431-2435.
(182) Loft S, Poulsen HE, Vistisen
K, Knudsen LE. Increased urinary excretion of
8-oxo-2'-deoxyguanosine, a biomaker of oxidative DNA damage, in
urban bus drivers. Mutat Res 1999; 441:11-19.
(181) Loft S, Poulsen HE.
Measurement of oxidative damage to DNA: interpretation of
nuclear levels and urinary excretion of repair products in DNA
damage and Repair: Oxygen Radical effects, cellular protection
and biological consequeences. In: Karakaya A, Dizdaroglu M,
editors. Oxygen Radical Effects, Cellular Protection and
Biological Consequences. New York: Plenum Press, 1999: 267-281.
(180) Loft S, Poulsen HE. Markers of
oxidative damage to DNA: antioxidants and molecular damage.
Methods Enzymol 1999; 300:166-184.
(179) Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.
(178) Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.
(177) Salonen J, Nyyssonen K,
Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. The
Effect of Vitamin E and Vitamin C on Carotid Atherosclerotic
Progression: The Antioxidant Supplementation in Atherosclerosis
Prevention (ASAP) study. Circulation 1999; Suppl. 100:I-238.
(176) Tuo J, Loft S, Poulsen HE.
Enhanced benzene-induced DNA damage in PMA-stimulated cells in
vitro and in LPS-treated animals. Free Rad Biol Med 1999;
26:801-808.
(175) Tuo J, Deng X, Loft S, Poulsen
HE. Dexamethasone ameliorates oxidative DNA damage induced by
benzene and LPS in mouse bone marrow. Free Rad Res 1999;
30:29-36.
1998
(174) Deng XS, Tuo J, Poulsen HE,
Loft S. Prevention of oxidative DNA damage in rats by brussels
sprouts. Free Rad Res 1998; 28(3):323-333.
(173) Haderslev KV, Sonne J, Poulsen
HE, Loft S. Paracetamol metabolism in patients with ulcerative
colitis. British Journal of Clinical Pharmacology 1998;
46:513-516.
(172) Loft S, Poulsen HE. Markers of
oxidative damage to DNA: Antioxidants and molecular damage.
Methods Enzymol 1998; 300:166-184.
(171) Loft S, Deng XS, Tuo J,
Wellejus A, Sorensen M, Poulsen HE. Experimental study of
oxidative DNA damage. Free Rad Res 1998; 29:525-539.
(170) Loft S, Thorling EB, Poulsen
HE. High fat diet induced oxidative DNA damage estimated by
8-oxo-7,8-dehydro-2'-deoxyguanosine excretion in rats. Free Rad
Res 1998; 29:595-600.
(169) Loft S, Poulsen HE. Estimation
of oxidative DNA damage in man from urinary excretion of repair
products. Acta Biochim Pol 1998; 45:133-144.
(168) Porkkala SE, Nyyssonen MK,
Kaikkonen JE, Poulsen HE, Hayn EM, Salonen RM et al. A
randomized, single-blind, placebo-controlled trial of the
effects of 200 mg alpha -tocopherol on the oxidation resistance
of atherogenic lipoproteins. Am J Clin Nutr 1998;
68/5(1034-1041):-1041.
(167) Poulsen HE, Loft S.
Interpretation of oxidative DNA modification: Relation between
tissue levels, excretion of urinary repair products and sigle
cell gel electrophoresis (comet assay). In: Aruoma OI, Halliwell
B, editors. DNA & free radicals: Techniques, mechanisms and
applications. London: OICA International, 1998: 261-270.
(166) Poulsen HE. [Medication
errors--the top of an iceberg? (editorial)]. Ugeskr Laeger 1998;
160(27):4041.
(165) Poulsen HE, Weimann A, Salonen
JT, Nyyssonen K, Loft S, Cadet J et al. Does vitamin C have a
pro-oxidant effect? [letter]. Nature 1998; 395(6699):231-232.
(164) Poulsen HE, Loft S, Prieme H,
Vistisen K, Lykkesfeldt J, Nyyssonen K et al. Oxidative DNA
damage in Vivo: Relationship to age, plasma antioxidants, drug
metabolism, glutathione-S-transferase activity and urinary
creatinine excretion. Free Rad Res 1998; 29:565-571.
(163) Poulsen HE, Prieme H, Loft S.
Role of oxidative DNA damage in cancer initiation and promotion.
European Journal of Cancer Prevention 1998; 7(1):9-16.
(162) Prieme H, Nyyssonen K,
Gronbaek K, Klarlund M, Loft S, Tonnesen P et al. Randomized
controlled smoking cessation study: transient increase in plasma
high density lipoprotein but no change in lipoprotein oxidation
resistance. Scand J Clin Lab Invest 1998; 58(1):11-18.
(161) Prieme H, Loft S, Klarlund M,
Gronbaek K, Tonnesen P, Poulsen HE. Effect of smoking cessation
on oxidative DNA modification estimated by
8-oxo-7,8-dihydro-2'-deoxyguanosine excretion. Carcinogenesis
1998; 19(2):347-351.
(160) Tuo J, Wolff SP, Loft S,
Poulsen HE. Formation of nitrated and hydroxylated aromatic
compounds from benzene and peroxynitrite, a possible mechanism
of benzene genotoxicity. Free Rad Res 1998; 28(4):369-375.
1997
(159) Cadenas S, Barja G, Poulsen
HE, Loft S. Oxidative DNA damage estimated by oxo8dG in the
liver of guinea-pigs supplemented with graded dietary doses of
ascorbic acid and alpha-tocopherol. Carcinogenesis 1997;
18(12):2373-2377.
(158) Deng XS, Tuo J, Poulsen HE,
Loft S. 2-Nitropropane-induced DNA damage in rat bone marrow.
Mutat Res 1997; 391(3):165-169.
(157) Kaikkonen J, Nyyssonen K,
Porkkala SE, Poulsen HE, Metsa KT, Hayn M et al. Effect of oral
coenzyme Q10 supplementation on the oxidation resistance of
human VLDL+LDL fraction: absorption and antioxidative properties
of oil and granule-based preparations. Free Rad Biol Med 1997;
22(7):1195-1202.
(156) Kaikkonen J, Nyyssonen K,
Porkkala-Sarataho E, Poulsen HE, Metsa-Ketela T, Hayn M et al.
Effect of oral coenzyme Q10 supplementation on the oxidation
resistance of human VLDL+LDL fraction: absorption and
antioxidative properties of oil and granule-based preparations.
Free Rad Biol Med 1997; 22(7):1195-1202.
(155) Klarlund M, Prieme H, Loft S,
Poulsen HE. Smoking cessation does not change urinary albumin
excretion in normal subjects. Scand J Clin Lab Invest 1997;
(154) Lykkesfeldt J, Loft S, Nielsen
JB, Poulsen HE. Ascorbic acid and dehydroascorbic acid as
biomarkers of oxidative stress caused by smoking. Am J Clin Nutr
1997;
(153) Nyyssonen K, Poulsen HE, Hayn
M, Agerbo P, Porkkala-Sarataho E, Kaikkonen J et al. Effect of
supplementation of smoking men with plain or slow release
ascorbic acid on lipoprotein oxidation. European Journal of
Clinical
(152) Poulsen HE. [Adverse effects of drugs--25 years later (editorial)]. Ugeskr Laeger 1997; 159(33):4964.
(151) Poulsen HE, Loft S, Prieme H,
Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary
microcirculation during ischaemia and reperfusion. Copenhagen:
Munksgaard, 1997: 455-461.
(150) Prieme H, Loft S, Nyyssonen K,
Salonen JT, Poulsen HE. No effect of supplementation with
vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA
damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine
excretion in smokers. Am J Clin
(149) Vistisen K, Prieme H, Okkels
H, Vallentin S, Loft S, Olsen JH et al. Genotype and phenotype
of glutathione S-transferase mu in testicular cancer patients. Pharmacogenetics. 1997
Feb;7(1):21-5.
1996
(148) Clemmensen JO, Ott P, Dalhoff
KP, Astrup LB, Tage-Jensen U, Poulsen HE. Rekommandation for
behandling af paracetamolforgiftning. Ugeskr Laeger 1996;
158:6892-6895.
(147) Jensen KG, Poulsen HE, Doehmer
J, Loft S. Paracetamol-induced spindle disturbances in V79 cells
with and without expression of human CYP1A2. Pharmacology and
Toxicology 1996; 78(4):224-228.
(146) Jeppesen U, Loft S, Poulsen
HE, Brosen K. A fluvoxamine-caffeine interaction study.
Pharmacogenetics 1996; 6(3):213-222.
(145) Jeppesen U, Gram LF, Vistisen
K, Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of
CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine,
fluvoxamine and paroxetine. European Journal of Clinical
Pharmacology 1996; 51(1):73-78.
(144) Laursen JB, Boesgaard S,
Poulsen HE, Aldershvile J. Nitrate tolerance impairs nitric
oxide-mediated vasodilation in vivo. Cardiovasc Res 1996;
31(5):814-819.
(143) oft S, Poulsen HE. Cancer
risk and oxidative DNA damage in man. J Mol Med 1996;
74(6):297-312.
(142) Loft S, Jensen KG, Ringby L,
Poulsen HE, Doehmer J. Kinetic studies in engineered V79 cells
in comparison with primary hepatocytes and human liver
microsomes. Experimental and Toxicologic Pathology 1996;
48:249-256.
(141) Lykkesfeldt J, Prieme H, Loft
S, Poulsen HE. Effect of smoking cessation on plasma ascorbic
acid concentration. British Medical Journal 1996; 313(7049):91.
(140) Poulsen HE, Loft S, Vistisen
K. Extreme exercise and oxidative DNA modification. J Sports Sci
1996; 14(4):343-346.
(139) Poulsen HE. [Markers of vitamin deficiencies (editorial)]. [Danish]. Ugeskr Laeger 1996; 158(27):3906.
(138) Prieme H, Loft S, Cutler RG,
Poulsen HE. Measurement of oxidative DNA injury in humans:
evaluation of a commercially available ELISA assay. In:
Kumpulainen JT, editor. Natural antioxidants and food quality in
atherosclerosis and cancer prevention. The royal society of
chemistry 1996, 1996: 78-82.
(137) Tuo J, Loft S, Thomsen MS,
Poulsen HE. Ex vivo time-dependent cell DNA-degradation shown by
single cell gel electrophoresis. Pharmacology and Toxicology
1996; 78(1):55-57.
(136) Tuo J, Loft S, Thomsen MS,
Poulsen HE. Benzene-induced genotoxicity in mice in vivo
detected by the alkaline comet assay: reduction by CYP2E1
inhibition. Mutat Res 1996; 368(3-4):213-219.
1995
(135) Fischer-Nielsen A, Corcoran
GB, Poulsen HE, Kamendulis LM, Loft S. Menadione-induced DNA
fragmentation without 8-oxo-2'-deoxyguanosine formation in
isolated. Biochem
Pharmacol. 1995 May 17;49(10):1469-74
(134) Jensen KG, Poulsen HE, Doehmer
J, Loft S. Kinetics and inhibition by fluvoxamine of phenacetin
O-deethylation in V79 cells expressing human CYP1A2.
Pharmacology and Toxicology 1995; 76(4):286-288.
(133) Loft S, Velthuis-te WE, Van
den Berg H, Poulsen HE. Energy restriction and oxidative DNA
damage in humans. Cancer Epidemiol Biomarkers Prev 1995;
4(5):515-519.
(132) Loft S, Larsen PN, Rasmussen
A, Fischer-Nielsen A, Bondesen S, Kirkegaard P et al. Oxidative
DNA damage after transplantation of the liver and small
intestine in pigs. Transplantation 1995; 59:16-20.
(131) ykkesfeldt J, Loft S, Poulsen
HE. Determination of ascorbic acid and dehydroascorbic acid in
plasma by high-performance liquid chromatography with
coulometric detection--are they reliable biomarkers of oxidative
stress? Anal Biochem 1995; 229(2):329-335.
(130) Nielsen HB, Hanel B, Loft S,
Poulsen HE, Pedersen BK, Diamant M et al. Restricted pulmonary
diffusion capacity after exercise is not an ARDS-like injury. J
Sports Sci 1995; 13(2):109-113.
(129) Poulsen HE, Loft S. Early
biochemical markers of effects: enzyme induction, oncogene
activation and markers of oxidative damage. Toxicology 1995;
101(1-2):55-64.
(128) Rasmussen BB, Maenpaa J,
Pelkonen O, Loft S, Poulsen HE, Lykkesfeldt J et al. Selective
serotonin reuptake inhibitors and theophylline metabolism in
human liver microsomes: potent inhibition by fluvoxamine. Br J
Clin Pharmacol 1995; 39(2):151-159.
(127) Thomsen MS, Loft S, Roberts
DW, Poulsen HE. Cytochrome P4502E1 inhibition by propylene
glycol prevents acetaminophen (paracetamol) hepatotoxicity in
mice without cytochrome P4501A2 inhibition. Pharmacology and
Toxicology 1995; 76(6):395-399.
(126) an Poppel G, Poulsen HE, Loft
S, Verhagen H. No influence of beta carotene on oxidative DNA
damage in male smokers. J Nat Can Inst 1995; 87:310-311.
(125) Velthuis-te WE, van Leeuwen
RE, Hendriks HF, Verhagen H, Loft S, Poulsen HE et al.
Short-term moderate energy restriction does not affect
indicators of oxidative stress and genotoxicity in humans.
Journal of Nutrition 1995; 125(10):2631-2639.
(124) Verhagen H, Poulsen HE, Loft
S, van Poppel G, Willems MI, van Bladeren PJ. Reduction of
oxidative DNA-damage in humans by brussels sprouts.
Carcinogenesis 1995; 16(4):969-970.
1994
(123) Boesgaard S, Iversen HK,
Wroblewski H, Poulsen HE, Frandsen H, Kastrup J et al. Altered
peripheral vasodilator profile of nitroglycerin during long-term
infusion of N-acetylcysteine. J Am Coll Cardiol 1994;
23(1):163-169.
(122) Boesgaard S, Aldershvile J,
Poulsen HE, Loft S, Anderson ME, Meister A. Nitrate tolerance in
vivo is not associated with depletion of arterial or venous
thiol levels. Circ Res 1994; 74(1):115-120.
(121) Kjoller-Hansen L, Boesgaard S,
Laursen JB, Poulsen HE, Aldershvile J. [Nitroglycerin
preparations. Effect and tolerance]. [Review] [38 refs]
[Danish]. Ugeskr Laeger 1994; 156(24):3621-3625.
(120) Laursen JB, Boesgaard S,
Poulsen HE, Aldershvile J. Endotelderiveret relakserende
faktor/nitrogenoxid. Ugeskr Laeger 1994; 156:5661-5666.
(119) Loft S, Astrup A, Buemann B,
Poulsen HE. Oxidative DNA damage correlates with oxygen
consumption in humans. Faseb J 1994; 8(8):534-537.
(118) Lykkesfeldt J, Loft S, Poulsen
HE. Simultaneous determination of urinary free cortisol and 6
beta-hydroxycortisol by high-performance liquid chromatography
to measure human CYP3A activity. J Chromatogr B Biomed Appl
1994; 660(1):23-29.
(117) Poulsen HE, Loft S. The impact
of genetic polymorphisms in risk assessment of drugs. [Review]
[73 refs]. Arch Toxicol Suppl 1994; 16:211-222.
(116) Sandstrøm B, Astrup A,
Dyerberg J, Hølmer G, Poulsen HE, Stender S et al. Den
sundhedsmæssige betydning af antioxidanter i levnedsmidler og
som kosttilskud. Ugeskr Laeger 1994; 156:7675-7679.
1993
(115) Boesgaard S, Poulsen HE,
Aldershvile J, Loft S, Anderson ME, Meister A. Acute effects of
nitroglycerin depend on both plasma and intracellular sulfhydryl
compound levels in vivo. Effect of agents with different
sulfhydryl-modulating properties. Circulation 1993;
87(2):547-553.
(114) Boesgaard S, Aldershvile J,
Poulsen HE, Christensen S, Dige-Petersen H, Giese J.
N-acetylcysteine inhibits angiotensin converting enzyme in vivo.
J Pharmacol Exp Ther 1993; 265(3):1239-1244.
(113) Brosen K, Skjelbo E, Rasmussen
BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of
cytochrome P4501A2. Biochem Pharmacol 1993; 45(6):1211-1214.
(112) Dalhoff K, Poulsen HE.
Inhibition of acetaminophen oxidation by cimetidine and the
effects on glutathione and activated sulphate synthesis rates.
Pharmacology and Toxicolgy.1993, 73, 215-8
(111) Dalhoff K, Poulsen HE.
Simultaneous measurements of glutathione and activated sulphate
(PAPS) synthesis rates and the effects of selective inhibition
of glutathione conjugation or sulphation of acetaminophen.
Biochem Pharmacol 1993; 46(3):383-388.
(110) Dalhoff K, Poulsen HE.
Synthesis rates of glutathione and activated sulphate (PAPS) and
response to cysteine and acetaminophen administration in
glutathione-depleted rat hepatocytes. Biochem Pharmacol
1993; 46(7):1295-1297.
(109) Ding JW, Andersson R, Soltesz
V, Willen R, Loft S, Poulsen HE et al. The effect of biliary
decompression on bacterial translocation in jaundiced rats. Hpb
Surg 1993; 7(2):99-110.
(108) Jeding IB, Loft S, Poulsen HE.
Non-induction of extrahepatic antipyrine and metronidazole
metabolism evaluated from partially hepatectomized rats.
Xenobiotica 1993; 23(4):411-418.
(107) Jensen KG, Onfelt A, Poulsen
HE, Doehmer J, Loft S. Effects of benzo[a]pyrene and
(+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in
Chinese hamster V79 cells with stable expression of rat
cytochrome P4501A1 or 1A2. Carcinogenesis 1993;
14(10):2115-2118.
(106) Jensen KG, Loft S, Doehmer J,
Poulsen HE. Metabolism of phenacetin in V79 Chinese hamster cell
cultures expressing rat liver cytochrome P4501A2 compared to
isolated rat hepatocytes. Biochem Pharmacol 1993;
45(5):1171-1173.
(105) Kjoller-Hansen L, Boesgaard S,
Laursen JB, Aldershvile J, Poulsen HE. [Importance of thiols (SH
group) in the cardiovascular system]. [Review] [37 refs]
[Danish]. Ugeskr Laeger 1993; 155(45):3642-3645.
(104) Loft S, Fischer-Nielsen A,
Jeding IB, Vistisen K, Poulsen HE. 8-Hydroxydeoxyguanosine as a
urinary biomarker of oxidative DNA damage. J Toxicol Environ
Health 1993; 40(2-3):391-404.
(103) Poulsen HE, Vilstrup H, Almdal
T, Dalhoff K. No net splanchnic release of glutathione in man
during N-acetylcysteine infusion. Scand J Gastroenterol 1993;
28(5):408-412.
(102) Poulsen HE, Roberts DW, Hinson
JA. Covalent binding of acetaminophen estimated from protein
adducts. In: Jeffery EH, editor. Human Drug Metabolism. From
molecular biology to man. Boca Raton, Ann Arbor, London, Tokyo:
CRC Press,
(101) Poulsen HE, Loft S, Wassermann
K. Cancer risk related to genetic polymorphisms in carcinogen
metabolism and DNA repair. [Review] [93 refs]. Pharmacology and
Toxicology 1993; 72:Suppl-103.
(100) Ranek L, Dalhoff K, Poulsen
HE, Brøsen K, Flacks H, Loft S. Drug metabolism in subjects with
previous halothane hepatitis. Scand J Gastroenterol 1993;
28:677-680.
(99) Ranek L, Dalhoff K, Poulsen
HE, Brosen K, Flachs H, Loft S et al. Drug metabolism and
genetic polymorphism in subjects with previous halothane
hepatitis. Scand J Gastroenterol 1993; 28(8):677-680.
(98) Sherson DL, Sigsgaard TI,
Overgaard E, Loft SH, Poulsen HE, Jongeneelen FC. [Risk of lung
cancer among foundry workers]. [Danish]. Ugeskr Laeger 1993;
155(9):620-623.
1992
(97) Boesgaard S, Aldershvile J,
Poulsen HE. Preventive administration of intravenous
N-acetylcysteine and development of tolerance to isosorbide
dinitrate in patients with angina pectoris. Circulation 1992;
85(1):143-149.
(96) Dalhoff K, Ranek L, Mantoni M,
Poulsen HE. Glutathione treatment of hepatocellular carcinoma.
Liver 1992; 12(5):341-343.
(95) Dalhoff K, Poulsen HE. Effects
of cysteine and acetaminophen on the syntheses of glutathione
and adenosine 3'-phosphate 5'-phosphosulfate in isolated rat
hepatocytes. Biochem Pharmacol 1992; 44(3):447-454.
(94) Fischer-Nielsen A, Poulsen HE,
Loft S. 8-Hydroxydeoxyguanosine in vitro: effects of
glutathione, ascorbate, and 5-aminosalicylic acid. Free Rad Biol
Med 1992; 13(2):121-126.
(93) Loft S, Vistisen K, Ewertz M,
Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage
estimated by 8-hydroxydeoxyguanosine excretion in humans:
influence of smoking, gender and body mass index. Carcinogenesis
1992;13(12):2241-2247.
(92) Loft S, Otte J, Poulsen HE,
Sorensen H. Influence of intact and myrosinase-treated indolyl
glucosinolates on the metabolism in vivo of metronidazole and
antipyrine in the rat. Food Chem Toxicol 1992; 30(11):927-935.
(91) Poulsen HE, Loft S, Andersen M,
Andersen JR. Disulfiram therapy - adverse drug reactions and
interactions. Acta Scand Psych 1992; 86:59-66.
(90) Sherson D, Sigsgaard T,
Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of
smoking, uptake of polycyclic aromatic hydrocarbons, and
cytochrome P450IA2 activity among foundry workers. Br J Ind Med
1992; 49(3):197-202.
(89) Vistisen K, Poulsen HE, Loft S.
Foreign compound metabolism capacity in man measured from
metabolites of dietary caffeine. Carcinogenesis 1992;
13(9):1561-1568.
1991
(88) Andersson R, Poulsen HE, Ahren
B. Effect of bile on liver function tests in experimental E.
coli peritonitis in the rat. Hepatogastroenterology 1991;
38(5):388-390.
(87) Boesgaard S, Petersen JS,
Aldershvile J, Poulsen HE, Flachs H. Nitrate tolerance: effect
of thiol supplementation during prolonged nitroglycerin infusion
in an an in vivo rat model. J Pharmacol Exp Ther 1991;
258(3):851-856.
(86) Dalhoff K, Hansen PB, Ott P,
Loft S, Poulsen HE. Acute ethanol administration reduces the
antidote effect of N-acetylcysteine after acetaminophen overdose
in mice. Hum Exp Toxicol 1991; 10(6):431-433.
(85) Fischer-Nielsen A, Poulsen HE,
Hansen BA, Hage E, Keiding S. CCl4 cirrhosis in rats:
irreversible histological changes and differentiated functional
impairment. J Hepatol 1991; 12(1):110-117.
(84) Loft S, Nielsen AJ, Borg BE,
Poulsen HE. Metronidazole and antipyrine metabolism in the rat:
clearance determination from one saliva sample. Xenobiotica
1991; 21(1):33-46.
(83) Loft S, Otton SV, Lennard MS,
Tucker GT, Poulsen HE. Characterization of metronidazole
metabolism by human liver microsomes. Biochem Pharmacol 1991;
41(8):1127-1134.
(82) Poulsen HE, Ranek L, Jorgensen
L. The influence of disulfiram on acetaminophen metabolism in
man. Xenobiotica 1991; 21(2):243-249.
(81) Roberts DW, Benson RW, Pumford,
NR, Potter DW, Poulsen HE et al. Sensitive immunochemical assays
for monitoring acetaminophen toxicity in humans. In: Vanderlaan
M, editor. Immunoassays for trace chemical analysis. Washington
DC:
(80) Sjovall S, Ahren B, Hansson P,
Loft S, Poulsen HE, Bengmark S. Metabolic responses to
intermittent hepatic dearterialization in the rat. J
Hepatol 1991; 13(1):33-37.
(79) Vistisen K, Loft S, Poulsen HE.
Cytochrome P450 IA2 activity in man measured by caffeine
metabolism: effect of smoking, broccoli and exercise. Adv Exp
Med Biol 1991; 283:407-411.
1990
(78) Hinson JA, Roberts DW, Benson
RW, Dalhoff K, Loft S, Poulsen HE. Mechanism of paracetamol
toxicity. Lancet 1990; 335(8691):732.
(77) Loft S, Poulsen HE. Prediction
of xenobiotic metabolism by non-invasive methods. [Review] [104
refs]. Pharmacology and Toxicology 1990; 67(2):101-108.
(76) Loft S, Poulsen HE. Metabolism
of metronidazole and antipyrine in hepatocytes isolated from
mouse and rat. Xenobiotica 1990; 20(2):185-191.
(75) Loft S, Egsmose C, Sonne J,
Poulsen HE, Dossing M, Andreasen PB. Metronidazole elimination
is preserved in the elderly. Hum Exp Toxicol 1990; 9(3):155-159.
(74) Ott P, Hansen PB, Dalhoff KP,
Loft SH, Poulsen HE. [Consumption of, overdose and fatal
poisoning with analgesics in Denmark 1979-1986]. Ugeskr Laeger
1990; 152(4):250-252.
(73) Ott P, Dalhoff KP, Poulsen HE.
[Analgesic-induced.mortality (letter)]. Ugeskr Laeger
1990;152(39):2867-2868.
(72) Ott P, Dalhoff K, Hansen PB,
Loft S, Poulsen HE. Consumption, overdose and death from
analgesics during a period of over-the-counter availability of
paracetamol in in Denmark. J Intern Med 1990;
227(6):423-428
(71) Sonne J, Boesgaard S, Poulsen
HE, Loft S, Hansen JM, Dossing M et al. Pharmacokinetics and
pharmacodynamics of oxazepam and metabolism of paracetamol in
severe hypothyroidism. Br J Clin Pharmacol 1990; 30(5):737-742.
1989
(70) Fischer-Nielsen A, Poulsen HE,
Hansen BA, Tygstrup N, Keiding S. Age dependence of rat liver
function measurements. J Hepatol 1989; 9(2):190-197.
(69) Loft S, Poulsen HE. Metabolism
of metronidazole and antipyrine in isolated rat hepatocytes.
Influence of sex and enzyme induction and inhibition. Biochem
Pharmacol 1989; 38(7):1125-1136.
(68) Perrild H, Kayser L, Poulsen
HE, Skovsted L, Jorgensen B, Hansen JM. Differential effect of
continuous administration of beta-adrenoceptor antagonists on
antipyrine and phenytoin clearance. Br J Clin Pharmacol
1989;28(5):551-554.
(67) Poulsen HE, Hansen BA, Egeberg
JC. Neutral red changes arginine-induced glucagon and insulin
response in the rat. Pharmacology and Toxicology 1989;
65(1):65-68.
(66) Tvede KG, Loft S, Poulsen HE,
Schou JS. Methyl parathion toxicity in rats is changed by
pretreatment with the pesticides chlordecone, mirex and
linuron.Arch Toxicol Suppl 1989; 13:446-447.
1988
(65) Jorgensen L, Thomsen P, Poulsen
HE. Disulfiram prevents acetaminophen hepatotoxicity in rats.
Pharmacology and Toxicology 1988; 62(5):267-271.
(64) Knudsen GM, Poulsen HE, Paulson
OB. Blood-brain barrier permeability in galactosamine-induced
hepatic encephalopathy. No evidence for increased
GABA-transport. J Hepatol 1988; 6(2):187-192.
(63) Knudsen GM, Poulsen HE.
Unchanged blood-brain barrier permability to GABA in
experimental hepatic encephalopathy. In: Soeter PB, Wilson JHP,
Maijer AJ, Holm E, editors. Advances in ammonia metabolism and
hepatic encephalopathy. Elsevier Science Publishers B.V., 1988:
309-313.
(62) Loft S, Poulsen HE, Sonne J,
Dossing M. Metronidazole clearance: a one-sample method and
influencing factors. Clin Pharmacol Ther 1988; 43(4):420-428.
(61) Loft S, Dossing M, Sonne J,
Dalhof K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on
the pharmacokinetics and metabolism of a single oral dose of
metronidazole. European Journal of Clinical Pharmacology 1988; ;
35(1):65-68.
(60) Loft S, Dossing M, Poulsen HE.
Influence of age and consumption of tobacco, alcohol and
caffeine on on antipyrine clearance. Hum Toxicol 1988;
7(3):277-280.
(59) Poulsen HE, Thomsen P.
Long-term administration of toxic doses of paracetamol
(acetaminophen) to rats. Liver 1988; 8(3):151-156.
(58) Poulsen HE, Loft S. Antipyrine
as a model drug to study hepatic drug-metabolizing capacity. J
Hepatol 1988; 6(3):374-382.
(57) Sonne J, Poulsen HE, Loft S,
Dossing M, Vollmer-Larsen A, Simonsen K et al. Therapeutic doses
of codeine have no effect on acetaminophen clearance or
metabolism. European Journal of Clinical Pharmacology 1988;
35(1):109-111.
(56) Vilstrup H, Hansen BA, Almdal
T, PetersenKF, Siggaard I, Poulsen HE. The capacity of urea
synthesis in rats: regulation and physiological importance. In:
Soeters PB, editor. Advances in ammonia metabolism and hepatic
encephalopathy. Elsevier Science Publisheres B.V., 1988: 79-85
1987
(55) Adelhøj B,
Petring OU, Frosig F, Jensen BN, Ibsen M, Poulsen HE. The effect
of spinal analgesia and surgery on peroperative drug absorption
and gastric emptying in man.Acta Anaesth Scand 1987;
31(2):165-167.
(54) Dalhoff K, Poulsen HE, Garred P,
Placchi M, Gammans RE, Mayol RF et al. Buspirone
pharmacokinetics in patients with cirrhosis. Br J Clin Pharmacol
1987; 24(4):547-550.
(53) Loft S, Sonne J, Poulsen HE,
Petersen KT, Jorgensen BG, Dossing M. Inhibition and induction
of metronidazole and antipyrine metabolism. European Journal of
Clinical Pharmacology 1987; 32(1):35-41.
(52) Petersen KF, Hansen BA, Poulsen HE.
Hepatic regeneration following glucagon treatment. Horm Metab
Res 1987; 19(6):239-241.
(51) Petring OU, Adelhøj B, Ibsen M,
Poulsen HE. Effect of chlorpromazine on drug absorption and
gastric emptying in man. Can J Anaesth 1987; 34(6):563-565.
(50) Poulsen HE, Loft S. Quantitation of
liver function: Antipyrine, an update. In: Okolicsanyi L,
editor. Assessment and management of hepatobiliary disease.
Berlin Heidelberg: Springer-Verlag, 1987: 189-195.
(49) Poulsen HE, Jorgensen L, Thomsen P.
Prevention of acetaminophen hepatotoxicity by disulfiram.
Pharmacol Ther 1987; 33(1):83.
(48) Sonne J, Dossing M, Poulsen HE,
Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant
administration of cimetidine and phenobarbital on antipyrine
elimination and metabolite formation. Int J Clin Pharmacol Ther
Toxicol 1987; 25(4):194-196.
(47) Tygstrup N, Poulsen HE.
Post-marketing surveillance of hepatotoxicity. Milan, Italy:
Wichtig Editore, 1987.
1986
(46) Hansen BA, Poulsen HE. The capacity
of urea-N synthesis as a quantitative measure of the liver mass
in rats. J Hepatol 1986; 2(3):468-474.
(45) Hansen BA, Poulsen HE. Changes in
the hepatic capacity of urea-N synthesis, galactose elimination
and antipyrine clearance following 70% hepatectomy in the rat.
Scand J Clin Lab Invest 1986; 46:233-237.
(44) Hansen BA, Poulsen HE. Starvation
induced changes in quantitative measures of liver function in
the rat. Clin Nutrit 1986; 5:213-216.
(43) Loft S, Dossing M, Poulsen HE, Sonne
J, Olesen KL, Simonsen K et al. Influence of dose and route of
administration on disposition of metronidazole and its major
metabolites. European Journal of Clinical Pharmacology 1986;
30(4):467-473.
(42) Loft S, Sonne J, Pilsgaard H,
Dossing M, Poulsen HE, Ciraulo DA et al. Inhibition of
antipyrine elimination by disulfiram and cimetidine: the effect
of concomitant administration Pharmacokinetic interaction of
disulfiram and antidepressants. British Journal of Clinical
Pharmacology 1986; 21:75-77.
(41) Petring OU, Adelhøj B, Ibsen M,
Poulsen HE. The relationship between gastric emptying of
semisolids and paracetamol absorption. Br J Clin Pharmacol 1986;
22(6):659-662.
(40) Sonne J, Poulsen HE, Andreasen PB.
Single dose oxazepam has no effect on acetaminophen clearance or
metabolism. European Journal of Clinical Pharmacology 1986 ;
30(1):127-129.
1985
(39) Adelhøj B, Petring OU, Brynnum
J, Ibsen M, Poulsen HE. Effect of diazepam on drug absorption
and gastric emptying in man. Br J Anaesth 1985;
57(11):1107-1109.
(38) Adelhøj B, Petring OU, Ibsen M,
Brynnum J, Poulsen HE. Buprenorphine delays drug absorption and
gastric emptying in man. Acta Anaesth Scand 1985; 29(6):599-601.
(37) Adelhøj B, Petring OU, Ibsen M,
Brynnum J, Poulsen HE. Tardiv respirationsdepression efter
intravenøs buprenorfin. Ugeskr Laeger 1985; 147:1343.
(36) Petring OU, Adelhøj B, Ibsen M,
Brynnum J, Poulsen HE. Abstaining from cigarette smoking has no
major effect on gastric emptying in habitual smokers. Br J
Anaesth 1985; 57(11):1104-1106
(35) Poulsen HE. One sample
antipyrine clearance after 90% partial hepatectomy in the rat.
Liver 1985; 5(4):200-204.
(34) Poulsen HE, Lerche A, Skovgaard
LT. Acetaminophen metabolism by the perfused rat liver twelve
hours after acetaminophen overdose. Biochem Pharmacol
1985;34(20):3729-3733.
(33) Poulsen HE, Pilsgaard H.
Antipyrine metabolism during hepatic regeneration in the rat.
Liver 1985; 5(4):196-199.
(32) Poulsen HE, Lerche A, Pedersen
NT. Phenobarbital induction does not potentiate hepatotoxicity
but accelerates liver cell necrosis from acetaminophen overdose
in the rat. Pharmacology 1985; 30(2):100-108.
(31) Poulsen HE, Gaub J, Iversen J.
Changes in quantitative measures of hepatic function after 90%
hepatectomy in rats. European Journal of Clinical
Investigation1985; 15(5):285-289.
(30) Poulsen HE, Lerche A, Pedersen
NT. Potentiated hepatotoxicity from concurrent administration of
acetaminophen and allyl alcohol to rats. Biochem Pharmacol
1985;34(6):727-731.
(29) Tvedegaard E, Poulsen HE,
Vilstrup H, Thomsen HK. Functional status of the liver during
chronic renal failure: an experimental study in the rabbit.
Liver 1985; 5(4):183-188.
1984
(28) Pilsgaard H, Poulsen HE. A
one-sample method for antipyrine clearance determination in
rats. Pharmacology 1984; 29(2):110-116.
(27) Poulsen HE, Vilstrup H, Keiding
S. Galactose elimination kinetics in perfused rat liver after
two thirds hepatectomy. Scand J Clin Lab Invest 1984;
44(2):155-158.
(26) Poulsen HE, Korsholm B.
Quantitative liver functions after administration of allyl
alcohol to rats. Acta Pharmacol Toxicol 1984; 54(2):120-123.
(25) Poulsen HE, Ranek L.
Paracetamolforgiftning. Ugeskr Laeger 1984; 146:4030-4033.
(24) Tvedegaard E, Poulsen HE,
Vilstrup H, Thomsen HK. Liver function during chronic renal
failure in rabbits. Experientia 1984; 40(11):1255-1256.
1983
(23) Dossing M, Volund A, Poulsen HE.
Optimal sampling times for minimum variance of clearance
determination. Br J Clin Pharmacol 1983; 15(2):231-235.
(22) Dossing M, Pilsgaard H,
Rasmussen B, Poulsen HE. Time course of phenobarbital and
cimetidine mediated changes in hepatic drug metabolism. European
Journal of Clinical Pharmacology 1983; 25(2):215-222.
(21) Poulsen HE. A pocket calculator
program to sort data. Comput Biol Med 1983; 13(4):299-301.
1982
(20) Dossing M, Poulsen HE, Andreasen
PB, Tygstrup N. A simple method for determination of antipyrine
clearance. Clin Pharmacol Ther 1982; 32(3):392-396.
1981
(19) Poulsen HE, Ranek L, Andreasen
PB. The hepatic glutathione content in liver diseases. Scand J
Clin LabInvest 1981; 41(6):573-576
(18) Poulsen HE, Petersen P, Vilstrup
H. Quantitative liver function and morphology after paracetamol
administration to rats. European Journal of Clinical
Investigation 1981; 11(3):161-164.
(17) Sonne J, Poulsen HE, Dossing M,
Larsen NE, Andreasen PB. Cimetidine clearance and
bioavailability in hepatic cirrhosis. Clin Pharmacol Ther 1981;
29(2):191-197.
(16) Yildirim SI, Poulsen HE.
Quantitative liver functions after 70% hepatectomy. European
Journal of Clinical Investigation 1981; 11(6):469-472.
1980
(15) Milandri M, Poulsen HE, Ranek L,
Andreasen PB. Effect of long-term disulfiram administration on
rat liver. Pharmacology 1980; 21(1):76-80.
1977
(14) Poulsen HE, Bengmark S, Borgeson
S, Flodgren P, Kallum B. Staging laparotomy with splenectomy in
Hodkin's disease. Acta Chir Scand 1977; 143:347-357.
1976
(13) Poulsen HE, Ranek L. [Duodenal ulcer
as a cause of splenic vein thrombosis and esophageal varices].
Ugeskr Laeger 1976 Jul 5;138(28):1712-3..
Monographs
(12) Poulsen HE. Kvantitering af leverfunktionen ved eksperimentel akut toksisk leverskade sammenlignet med forholdene efter partiel og subtotal hepatectomi. Disputats. Copenhagen: University of Copenhagen, 1986
Proceedings
(11) Lykkesfeldt J, Loft S, Poulsen HE.
Individuel kræftrisiko - biomarkører kan måske give os svaret.
Naturens Verden 1995; 78:32-40.
(10) Poulsen HE, Weimann A, Loft S.
Methods to detect DNA damage by free radicals: relation to
exercise. Proc Nutr Soc 1999 Nov;58(4):1007-14.
Book Chapters
2012
(9) Poulsen HE: Klinisk farmakologi og farmakoterapi. In: Basisbog i Diagnostiske Fag. Eds. Thomsen HS et al. Munksgaard Forlag. Kapitel 7 (2012) 251-268
2006
(8) Henrik E.
Poulsen, Allan Weimann and Berry B. Halliwell: Cigarette Smoke
and Oxidative DNA Modification in Cigarette Smoke and Oxidative
Stress. Ed. Berry B. Halliwell and Henrik E. Poulsen.
Springer-Verlag Berlin Heidelberg Chapter 16 (2006) 387-402.
2005
(7) Dalhoff K, Jensen KB, Poulsen HE.
Cancer and molecular biomarkers of phase 2. In: John Abelson,
USA, ed. Methods Enzymol. 400 ed. New York: Elsevier;
2005:618-27
2003
(6) Poulsen HE, Loft S, Jensen BR,
Sørensen, M, Hoberg A-M, Weimann A. HPLC-ECD, LC-MS/MS (Urinary
Biomarkers): In: Oxidative Stress and Aging. Advances in
Basic Science, Diagnostics, and Intervention, eds. Cutler RG,
Rodriguez H. Singapore: World Scientific Publishing Co. Pte.
Ltd; 2003:233-56(225)
(5) Poulsen HE. Proper design of human
intervention studies, power calculations. In:Free radicals,
nitric oxide, and inflammation: Molecular, biochemical, and
clinical aspects, eds. Tomasi A et al. Ohmsha: IOS Press;
2003:252-3.
(4) Poulsen HE. Estimation of oxidative
and lipids peroxidation DNA adduct in urine and DNA. Free
radicals, nitric oxide, and inflammation: Methodological aspects
and application in Molecular epidemiology.In: Molecular,
biochemical, and clinical aspects, eds. Tomasi A, et al. Ohmsha:
IOS Press; 2003:34-38
2002
(3) Griffiths HR, Møller L, Bartosz G,
Bast A, Bertoni-Freddari C, Collins A, Cooke M, Coolen S,
Haenen G, Hpberg AM, Loft S, Lunec J, Olinski R, Parry J,
Pompella A, Poulsen HE, Verhagen H, Astley SB. Chap 3;
Biomarkers. In Molecular Aspects of Medicine 23 2002; 101-208.
2000
(2) Poulsen HE, Loft S, Weimann A.
Urinary measurement of 8-oxodG (8-oxo-2'-deoxyguanosine). In:
Lunec J, Griffiths HR, editors. Measuring in vivo Oxidative
Damage: A practical Approach. London: John Wiley and Sons
(Ltd.), 2000: 69-80
1999
(1) Loft S, Poulsen HE. Measurement of
oxidative damage to DNA: interpretation of nuclear levels and
urinary excretion of repair products in DNA damage and Repair:
Oxygen Radical effects, cellular protection and biological
consequeences. In: Karakaya A, Dizdaroglu M, editors. Oxygen
Radical Effects, Cellular Protection and Biological
Consequences. New York: Plenum Press, 1999: 267-281.
Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.
Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.
1998
Poulsen HE, Loft S. Interpretation
of oxidative DNA modification: Relation between tissue levels,
excretion of urinary repair products and sigle cell gel
electrophoresis (comet assay). In: Aruoma OI, Halliwell B,
editors. DNA & free radicals: Techniques, mechanisms and
applications. London: OICA International, 1998: 261-270.
1997
Poulsen HE, Loft S, Prieme H,
Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary
microcirculation during ischaemia and reperfusion. Copenhagen:
Munksgaard, 1997: 455-461
1996
Prieme H, Loft S, Cutler RG, Poulsen
HE. Measurement of oxidative DNA injury in humans: evaluation of
a commercially available ELISA assay. In: Kumpulainen JT,
editor. Natural antioxidants and food quality in atherosclerosis
and cancer prevention. The royal society of chemistry 1996,
1996: 78-82.
1989
Roberts DW, Benson RW, Pumford, NR,
Potter DW, Poulsen HE et al. Sensitive immunochemical assays for
monitoring acetaminophen toxicity in humans. In: Vanderlaan M,
editor. Immunoassays for trace chemical analysis. Washington DC:
1989:44-50
1988
Knudsen GM, Poulsen HE. Unchanged
blood-brain barrier permability to GABA in experimental hepatic
encephalopathy. In: Soeter PB, Wilson JHP, Maijer AJ, Holm E,
editors. Advances in ammonia metabolism and hepatic
encephalopathy. Elsevier Science Publishers B.V., 1988: 309-313
Vilstrup H, Hansen BA, Almdal T,
PetersenKF, Siggaard I, Poulsen HE. The capacity of urea
synthesis in rats: regulation and physiological importance. In:
Soeters PB, editor. Advances in ammonia metabolism and hepatic
encephalopathy. Elsevier Science Publisheres B.V., 1988: 79-85
1987
Poulsen HE, Loft S. Quantitation of
liver function: Antipyrine, an update. In: Okolicsanyi L,
editor. Assessment and management of hepatobiliary disease.
Berlin Heidelberg: Springer-Verlag, 1987: 189-195.
Tygstrup N, Poulsen HE.
Post-marketing surveillance of hepatotoxicity. Milan, Italy:
Wichtig Editore, 1987.
Other Publications
2017
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https://dagenspharma.dk/clarithromycin-fremprovokerer-hjertekar-sygdom-ved-oxidere-rna/
1990
Poulsen HE, Juul P. Note on the statistical evaluation of a randomized, cross-over bioavailability study. Danish National Board of Health, 1990 PDF (289K)